Evidence map›Paper›PMID 40877515›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2025

Formulation and Characterization of Cationic Bicelles for siRNA Delivery.

Joan Cheng, Karunya K Kandimalla

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Joan ChengDepartment of Pharmaceutics and Brain Barriers Research Center, College of Pharmacy, University of Minnesota, Minneapolis, MN, USA.
Karunya K KandimallaDepartment of Pharmaceutics and Brain Barriers Research Center, College of Pharmacy, University of Minnesota, Minneapolis, MN, USA. kkandima@umn.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

First discovered in 1984, bicelles have been traditionally used for the structural characterization of membrane-associated proteins through nuclear magnetic resonance (NMR). However, interest has been growing over the past decade in their application to drug delivery. Discoidal particles, such as bicelles, have demonstrated a higher degree of cellular uptake in both in vitro and in vivo models compared to spherical particles, such as lipid nanoparticles. Favorable electrostatic interactions allow the cationic bicelles to efficiently load nucleic acids, including siRNA, for drug delivery and to readily dock onto the anionic cell surface for internalization via adsorptive endocytosis. In this chapter, we provide a detailed description of the formulation methods, an overview of the techniques that are employed for the characterization of the siRNA-bicelle complexes, and approaches to optimizing their cellular uptake.

Indexed as

Drug Delivery SystemsRNA, Small InterferingAnimalsCationsHumansLipidsNanoparticlesCationsLipidsRNA, Small InterferingCationic bicellesCellular uptakeDynamic light scattering (DLS)Electrophoretic light scattering (ELS)Gel electrophoresisLipid nanodiscsRibogreen assaysiRNA deliveryTransmission electron microscopy (TEM)

Identifiers

PMID40877515

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.