Evidence map›Paper›PMID 40877497›Full record

ArticleNeurocritical care2025

The Etiology Analysis of Myasthenia Gravis with In-Hospital Mortality in the Neurocritical Care Unit.

Hongxi Chen, Yuan Wang, Nana Zhang, Jie Song, Xue Lin, Chong Yan, Xiao Huan, Ziyan Shi, Xiaofei Wang, Ying Zhang and 10 more

Abstract read
PubMed Publisher
In one paragraph

Article in Neurocritical care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Hongxi Chen *Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.
Yuan Wang *Department of Blood Transfusion, Huashan Hospital, Fudan University, Shanghai, China.
Nana ZhangDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, China.
Jie SongHuashan Rare Disease Center and Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Xue LinDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, China.
Chong YanHuashan Rare Disease Center and Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Xiao HuanHuashan Rare Disease Center and Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Ziyan ShiDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, China.
Xiaofei WangDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, China.
Ying ZhangDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, China.
Qin DuDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, China.
Lingyao KongDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, China.
Dongren SunDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, China.
Rui WangDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, China.
Ziya WangDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, China.
Yangyang ZhangDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, China.
Jianying XiHuashan Rare Disease Center and Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Chongbo ZhaoHuashan Rare Disease Center and Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Hongyu ZhouDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, China.
Sushan LuoHuashan Rare Disease Center and Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China. luosushan@fudan.edu.cn.ORCID 0000-0002-9033-7568

Funding

Key Technologies Research and Development Program 2022YFC3501303Key Technologies Research and Development Program 2022YFC3501305National Natural Science Foundation of China 82471376National Natural Science Foundation of China 82471426
6 · The paper itself

Abstract

backgroundOur objective was to investigate the characteristics and causes of death in deceased patients with myasthenia gravis (MG).

methodsThis study conducted a retrospective analysis of data from patients with MG in the neurocritical unit at two large general hospitals in China spanning 10 years, from January 2014 to December 2023. Detailed demographic and clinical information were collected for deceased patients. Experienced physicians determined both the underlying and direct causes of death.

resultsAmong 3723 patients, the overall hospitalized mortality was 79 (2.12%). Thymoma was present in 52 (65.82%) of these patients. Compared with the nonthymomatous MG (NTMG) group (n = 27), patients with thymomatous MG (TMG) (n = 52) were significantly younger at death (53.71 ± 14.01 years vs. 65.37 ± 14.61 years, p = 0.001). Septic shock was the most common underlying cause of death, affecting 32 (40.51%) patients, followed by myasthenic crisis in 18 (22.78%) patients. This trend was observed in both the TMG and NTMG groups. In the TMG group, fulminant myocarditis was the third leading underlying cause of death in 9 (17.31%) patients, whereas no cases of fulminant myocarditis were reported in the NTMG group. Among all deceased patients (n = 79), pneumonia was the most common infection, affecting 55 (69.62%) patients, followed by urinary tract infections in 14 (17.72%) patients, bloodstream infections in 13 (16.46%) patients, and intracranial infections in 7 (8.86%) patients.

conclusionsThe study suggests that thymoma may increase the risk of death, with septic shock and myasthenic crisis being the most frequent underlying causes in patients with MG.

Indexed as

Hospital MortalityMyasthenia GravisShock, SepticThymomaThymus NeoplasmsAdultAgedAged, 80 and overCause of DeathChinaFemaleHumansMaleMiddle AgedRetrospective StudiesMortalityMyasthenia gravisMyasthenic crisisNeurocritical careSeptic shockThymoma

Identifiers

PMID40877497

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.