Evidence map›Paper›PMID 40877452›Full record

ArticleScientific reports2025

Linking cardiological parameters and choroidal changes in patients with precapillary pulmonary hypertension: a cross-sectional study.

Agnieszka Zonenberg, Katarzyna Ptaszyńska, Anna Szwedowicz, Emilia Sawicka-Śmiarowska, Remigiusz Kazimierczyk, Barbara Pieklarz, Izabela Zawadzka, Iwona Obuchowska, Aleksandra Leoniuk, Joanna Konopińska and 2 more

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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Agnieszka ZonenbergOphthalmology Department, Medical University of Bialystok, 24a M.Sklodowskiej-Curie St., Białystok, 15-276, Poland.
Katarzyna PtaszyńskaDepartment of Cardiology and Internal Diseases, Medical University of Bialystok, Białystok, Poland.ORCID http://orcid.org/0000-0002-6457-704X
Anna SzwedowiczOphthalmology Department, Medical University of Bialystok, 24a M.Sklodowskiej-Curie St., Białystok, 15-276, Poland.
Emilia Sawicka-ŚmiarowskaDepartment of Cardiology and Internal Diseases, Medical University of Bialystok, Białystok, Poland.ORCID http://orcid.org/0000-0002-8306-1882
Remigiusz KazimierczykDepartment of Cardiology and Internal Diseases, Medical University of Bialystok, Białystok, Poland.ORCID http://orcid.org/0000-0003-4517-1498
Barbara PieklarzOphthalmology Department, Medical University of Bialystok, 24a M.Sklodowskiej-Curie St., Białystok, 15-276, Poland.ORCID http://orcid.org/0000-0001-7857-5443
Izabela ZawadzkaOphthalmology Department, Medical University of Bialystok, 24a M.Sklodowskiej-Curie St., Białystok, 15-276, Poland.
Iwona ObuchowskaOphthalmology Department, Medical University of Bialystok, 24a M.Sklodowskiej-Curie St., Białystok, 15-276, Poland.ORCID http://orcid.org/0000-0002-8164-3782
Aleksandra LeoniukOphthalmology Department, Medical University of Bialystok, 24a M.Sklodowskiej-Curie St., Białystok, 15-276, Poland.
Joanna KonopińskaOphthalmology Department, Medical University of Bialystok, 24a M.Sklodowskiej-Curie St., Białystok, 15-276, Poland.ORCID http://orcid.org/0000-0002-9088-6938
Karol KamińskiDepartment of Cardiology and Internal Diseases, Medical University of Bialystok, Białystok, Poland.ORCID http://orcid.org/0000-0002-9465-2581
Diana A DmuchowskaOphthalmology Department, Medical University of Bialystok, 24a M.Sklodowskiej-Curie St., Białystok, 15-276, Poland. diana.dmuchowska@umb.edu.pl.ORCID http://orcid.org/0000-0002-3548-9139

Funding

Medical University of Bialystok, Poland B.SUB.23.526
6 · The paper itself

Abstract

Diagnosing precapillary pulmonary hypertension (PPH) is challenging, and prognosis remains poor. This study aims to explore the pathogenesis of choroidal changes in these patients and assess whether choroidal parameters could serve as noninvasive biomarkers reflecting cardiovascular status. This prospective, single-center study included 29 adult PPH patients and 37 healthy controls. One eye per patient was analyzed. All participants underwent a full ophthalmological examination, including spectral domain-optical coherence tomography, and a cardiological evaluation comprising medical history, physical examination, echocardiography, right heart catheterization, laboratory, and functional tests. Univariable regression analyses assessed associations between choroidal parameters and clinical, demographic, and ocular features. PPH patients showed significantly reduced choroidal thickness and volume in the ETDRS subfields compared to controls (p < 0.01 for all). However, luminal, stromal, and total choroidal areas, as well as the choroidal vascularity index, did not differ significantly between groups. No significant relationships were found between cardiological and choroidal parameters. The choroid is affected in PPH patients, but choroidal parameters do not appear to be reliable biomarkers for PPH evaluation. Further studies are needed to clarify the potential role of choroidal vascularity index in PPH.

Indexed as

ChoroidHypertension, PulmonaryAdultBiomarkersCase-Control StudiesCross-Sectional StudiesEchocardiographyFemaleHumansMaleMiddle AgedProspective StudiesTomography, Optical CoherenceBiomarkersBosentanChoroidChoroidal thicknessChoroidal vascularity indexPulmonary hypertensionSildenafilVascular bed

Identifiers

PMID40877452
PMCPMC12394444

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.