Trial reportJournal of perinatology : official journal of the California Perinatal Association2025
Dopamine versus epinephrine for neonatal septic shock: an open labeled, randomized controlled trial.
Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSeptic shock is one of the most common causes of neonatal mortality. Dopamine and epinephrine are the two main drugs used in fluid refractory neonatal septic shock. However, there is lack of consensus on use of first line agent in neonates. STUDY
designThis randomized, open labeled, controlled trial was conducted with primary objective to compare the proportion of patients achieving reversal of shock at 60 min of starting either dopamine or epinephrine as first line inotrope in neonates with fluid refractory septic shock.
resultsMore patients in the epinephrine group achieved reversal of shock than dopamine group (31 vs 25) but the difference was statistically not significant [p = 0.143, RR = 0.806 (95% CI 0.602,1.080)]. All-cause mortality was 87.5% (35/40) in the dopamine group and 85% (34/40) in the epinephrine group (34/40).
conclusionDopamine and epinephrine show equivalent efficacy in reversal of shock at 60 min in neonates with septic shock.
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