ArticleNature human behaviour2025
Spousal correlations for nine psychiatric disorders are consistent across cultures and persistent over generations.
Article in Nature human behaviour, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Population-Level Implications of Parental Similarity for the Prevalence and Heritability of Psychiatric Disorders.JAMA psychiatry · 2026Article
- Genetic trade-offs in fertility and longevity explain the maintenance of disease-associated alleles in humans.Nature ecology & evolution · 2026Article
- Spousal Dementia Exposure and Risk of Dementia.JAMA network open · 2026Article
- Borderline personality disorder and other psychiatric, somatic, and behavioral conditions: a nationwide family study.Translational psychiatry · 2026Article
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19 authors.
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Abstract
Trait similarities between spouses are a key factor that shapes the landscape of complex human traits. The driving force behind the spousal correlations can increase the overall prevalence of disorders, influence occurrences of comorbidities and bias estimations of genetic architectures. However, there is a lack of large-scale studies examining cultural differences and generational trends in spousal correlations for psychiatric disorders. Focusing on three national registries, we performed a large-scale analysis on spousal correlations across nine psychiatric disorders. We obtained the trait correlations from five million spousal pairs in Taiwan and then compared them with estimates from the Danish national registry (571,534 pairs) and with published results from the Swedish national registry (707,263 pairs). Generational changes in Taiwan for people born after the 1930s were investigated as well. We found that a majority of psychiatric disorders have consistent spousal correlations across nations and over generations, indicating their importance in the population dynamics of psychiatric disorders.
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