Evidence map›Paper›PMID 40877394›Full record

ArticleScientific reports2025

Cross-talk between dopamine and noradrenaline modulates glutamatergic transmission in the deep cerebellar nuclei.

Fumihito Saitow, Ryosuke Arakawa, Hidenori Suzuki

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Fumihito SaitowDepartment of Pharmacology, Nippon Medical School, Tokyo, 113-8602, Japan. f-saitow@nms.ac.jp.
Ryosuke ArakawaDepartment of Pharmacology, Nippon Medical School, Tokyo, 113-8602, Japan.
Hidenori SuzukiDepartment of Pharmacology, Nippon Medical School, Tokyo, 113-8602, Japan.

Funding

Ministry of Education, Culture, Sports, Science, and Technology (MEXT) in Japan 21500375
6 · The paper itself

Abstract

Modulation of synaptic transmission in the deep cerebellar nuclei, a major output region of the cerebellum, is essential for regulating motor and non-motor functions by controlling information flow from the cerebellar cortex. In this study, we aimed to investigate the effects of dopamine (DA) and noradrenaline (NA) on glutamatergic synaptic transmission using cerebellar slices from both male and female Wistar rats. Stimulation-evoked excitatory postsynaptic currents (eEPSCs) were recorded from deep cerebellar nuclei neurons using whole-cell patch-clamp technique. Bath application of DA or NA decreased the eEPSC amplitude. Pharmacological analysis revealed presynaptic D2-like receptors (D2R) and α

Indexed as

Cerebellar NucleiDopamineGlutamic AcidNorepinephrineSynaptic TransmissionAnimalsExcitatory Postsynaptic PotentialsFemaleMaleNeuronsRatsRats, WistarReceptors, Adrenergic, alpha-2Receptors, Dopamine D2DopamineGlutamic AcidNorepinephrineReceptors, Adrenergic, alpha-2Receptors, Dopamine D2Cross-talkD2 dopaminergic receptorDeep cerebellar nucleiGlutamatergic synaptic transmissionModulationα2-adrenergic receptor

Identifiers

PMID40877394
PMCPMC12394418

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.