Evidence map›Paper›PMID 40877339›Full record

ArticleScientific reports2025

The effect of hemoglobin level in early life on periventricular leukomalacia: a case control study.

Muchun Yu, Zhihong Sun, Lu He, Caiyu Zhang, Huiqing Sun

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Muchun YuDepartment of Neonatology, Children's Hospital affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Henan, 450018, China.
Zhihong SunDepartment of Neonatology, Children's Hospital affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Henan, 450018, China.
Lu HeDepartment of Neonatology, Children's Hospital affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Henan, 450018, China.
Caiyu ZhangDepartment of Neonatology, Children's Hospital affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Henan, 450018, China.
Huiqing SunDepartment of Neonatology, Children's Hospital affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Henan, 450018, China. s_huiqing@sina.com.

Funding

Henan Provincial Health Commission YXKC2021022
6 · The paper itself

Abstract

Periventricular leukomalacia (PVL) is a distinct form of brain injury that occurs in preterm infants. The aim of this study is to find suitable and easily accessible laboratory indicators for early prediction of PVL occurrence. A retrospective, case control study was conducted. Infants diagnosed with PVL were included and matched 1:3 with infants without PVL by sex and birth weight. A total of 364 infants were included in this study, including 91 in PVL group and 273 in control group. The hemoglobin (Hb) level (t = -2.961, p = 0.003) and red blood cell (RBC) count (t = -3.593, p < 0.001) in PVL group were lower than those in control group on the 7th day after birth. Logistic regression showed that the Hb level (OR = 0.984, 95%CI 0.972-0.996, p = 0.010) and the RBC count (OR = 0.120, 95%CI 0.034-0.424, p = 0.001) on the 7th day after birth were significantly correlated with the occurrence PVL disease. The receiver operating characteristic curve analysis showed that the cut-off value of Hb level on the 7th day after birth was 117.5 g/L (sensitivity = 0.553, specificity = 0.637) and the cut-off value of RBC count on the 7th day after birth was 3.025 × 10

Indexed as

HemoglobinsLeukomalacia, PeriventricularBirth WeightCase-Control StudiesErythrocyte CountFemaleHumansInfant, NewbornInfant, PrematureMaleRetrospective StudiesROC CurveHemoglobinsEarly lifeHemoglobinPeriventricular leukomalaciaPretermRed blood cell

Identifiers

PMID40877339
PMCPMC12394625

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