Evidence map›Paper›PMID 40877323›Full record

ArticleNature communications2025

Mechanistic origins of temperature scaling in the early embryonic cell cycle.

Jan Rombouts, Franco Tavella, Alexandra Vandervelde, Connie Phong, James E Ferrell, Qiong Yang, Lendert Gelens

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Frontiers in cell and developmental biology · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Jan Rombouts *Laboratory of Dynamics in Biological Systems, Department of Cellular and Molecular Medicine, KU Leuven, Herestraat, 49, Leuven, Belgium.ORCID http://orcid.org/0000-0003-4135-0771
Franco Tavella *Department of Physics / Biophysics, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-5997-6241
Alexandra VanderveldeLaboratory of Dynamics in Biological Systems, Department of Cellular and Molecular Medicine, KU Leuven, Herestraat, 49, Leuven, Belgium.
Connie PhongDepartment of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA.
James E FerrellDepartment of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-4767-3926
Qiong Yang *Department of Physics / Biophysics, University of Michigan, Ann Arbor, MI, USA. qiongy@umich.edu.ORCID http://orcid.org/0000-0002-2442-2094
Lendert Gelens *Laboratory of Dynamics in Biological Systems, Department of Cellular and Molecular Medicine, KU Leuven, Herestraat, 49, Leuven, Belgium. lendert.gelens@kuleuven.be.ORCID http://orcid.org/0000-0001-7290-9561

Funding

TRAINING & OUTREACH COREP50GM107615 · NIGMS · STANFORD UNIVERSITY · PI FERRELL, JAMES E. · 2013 to 2017
$10.9M
THE ROLE OF MAP KINASE IN THE CELL CYCLER01GM046383 · NIGMS · UNIVERSITY OF WISCONSIN MADISON · PI FERRELL, JAMES E. · 1991 to 2018
$7.3M
Cytoplasmic organization and systems-level function in Xenopus extractsR35GM131792 · NIGMS · STANFORD UNIVERSITY · PI JAMES E. FERRELL · 2019 to 2026
$5.6M
Understanding the robustness of cell cyclesR01GM144584 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Qiong Yang · 2023 to 2026
$1.2M
Fonds Wetenschappelijk Onderzoek (Research Foundation Flanders) G074321NNIGMS NIH HHS P50 GM107615NIGMS NIH HHS R01 GM046383NIGMS NIH HHS R01 GM144584NIGMS NIH HHS R35 GM131792
6 · The paper itself

Abstract

Temperature strongly influences physiological and ecological processes, particularly in ectotherms. While complex physiological rates often follow Arrhenius-like scaling, originally formulated for single reactions, the underlying reasons remain unclear. Here, we examine temperature scaling of the early embryonic cell cycle across six ectothermic species, including Xenopus, Danio rerio,  Caenorhabditis, and  Drosophila. We find remarkably consistent apparent activation energies (75  ± 7 kJ/mol), corresponding to a Q

Indexed as

Cell CycleEmbryo, NonmammalianTemperatureAnimalsDrosophilaXenopusXenopus laevisZebrafish

Identifiers

PMID40877323
PMCPMC12394406

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.