Evidence map›Paper›PMID 40877311›Full record

Trial reportNature communications2025

Long-term health outcomes in adolescents with obesity treated with faecal microbiota transplantation: 4-year follow-up.

Brooke C Wilson, Michele Zuppi, José G B Derraik, Benjamin B Albert, Ry Y Tweedie-Cullen, Karen S W Leong, Kathryn L Beck, Tommi Vatanen, Justin M O'Sullivan, Wayne S Cutfield and 1 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Review
  2. Review
  3. The gut microbiota in malnutrition.Nature reviews. Microbiology · 2026
    Review
  4. Review
  5. The Gut Microbiome-Endocrine Axis in Obesity: Mechanisms and Therapeutics.Journal of gastroenterology and hepatology · 2026
    Review
  6. Reframing obesity through the gut microbiota: functional dysbiosis and metabolic disease.Current opinion in clinical nutrition and metabolic care · 2026
    Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Brooke C WilsonLiggins Institute, University of Auckland, Auckland, New Zealand.ORCID http://orcid.org/0000-0002-2213-542X
Michele ZuppiLiggins Institute, University of Auckland, Auckland, New Zealand.
José G B DerraikDepartment of Paediatrics: Child & Youth Health, University of Auckland, Auckland, New Zealand.ORCID http://orcid.org/0000-0003-1226-1956
Benjamin B AlbertLiggins Institute, University of Auckland, Auckland, New Zealand.ORCID http://orcid.org/0000-0003-0498-3473
Ry Y Tweedie-CullenLiggins Institute, University of Auckland, Auckland, New Zealand.ORCID http://orcid.org/0000-0003-0128-7181
Karen S W LeongLiggins Institute, University of Auckland, Auckland, New Zealand.
Kathryn L BeckSchool of Sport, Exercise and Nutrition, Massey University, Auckland, New Zealand.
Tommi VatanenInstitute of Biotechnology, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0003-0949-1291
Justin M O'SullivanLiggins Institute, University of Auckland, Auckland, New Zealand. justin.osullivan@auckland.ac.nz.ORCID http://orcid.org/0000-0003-2927-450X
Wayne S CutfieldLiggins Institute, University of Auckland, Auckland, New Zealand. w.cutfield@auckland.ac.nz.ORCID http://orcid.org/0000-0001-6107-3682
Gut Bugs Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Faecal microbiota transplantation (FMT) has been explored as a potential treatment for obesity, but its long-term effects on metabolic health remain unclear. Here, we report 4-year follow-up findings from a double-blind, randomised, placebo-controlled trial assessing FMT in adolescents with obesity (ACTRN12615001351505, Australian New Zealand Clinical Trials Registry). This unblinded follow-up study evaluated 63% (55/87) of the original participants (27 FMT, 28 placebo). There was no difference in BMI between the two groups, after adjusting for sex, age, diet, and physical activity (-3.6 kg/m

Indexed as

Fecal Microbiota TransplantationObesityPediatric ObesityAdolescentBody CompositionBody Mass IndexDouble-Blind MethodFecesFemaleFollow-Up StudiesGastrointestinal MicrobiomeHumansMaleMetabolic SyndromeTreatment Outcome

Identifiers

PMID40877311
PMCPMC12394558

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.