ReviewIn vivo (Athens, Greece)
Superficial Angiomyxoma Revisited.
Review in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Superficial angiomyxoma (SAM) is a rare benign mesenchymal tumor of uncertain differentiation that primarily occurs in the trunk, lower extremities and head and neck of middle-aged adults. It typically presents as a slow-growing, painless polypoid or papulonodular lesion. Ultrasonography shows an ovoid, well-defined mass with a homogeneous, hypoechoic echotexture. Color Doppler examination may demonstrate prominent hypervascularity. Computed tomography reveals a round to oval hypodense mass. On magnetic resonance imaging, SAM usually exhibits low to intermediate signal intensity on T1-weighted sequences and high signal intensity on T2-weighted sequences. Heterogenous enhancement is seen after intravenous contrast administration. Histologically, the lesion is composed of bland spindle-shaped and stellate-shaped cells in an abundant myxoid stroma with numerous small blood vessels. By immunohistochemistry, the tumor cells are positive for CD34 and show variable staining for smooth muscle actin and S-100 protein. Loss of protein kinase cAMP-dependent type I regulatory subunit alpha (PRKAR1A) expression is observed in a significant subset of cases. Complete surgical excision is the treatment of choice for SAM. This review provides an updated overview of the clinicopathological, radiological and genomic features of SAM and discusses the differential diagnosis of this peculiar tumor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.