ArticleIn vivo (Athens, Greece)
Risk Factors for Radiation Pneumonitis and a Prognostic Instrument for Very Elderly Patients With Lung Cancer.
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Collagenous endobronchial obliteration after chemoradiation followed by consolidation osimertinib: a case report.Frontiers in oncology · 2026Article
- Pneumonitis in Older Patients With Non-squamous Non-small Cell Lung Cancer Treated With Pembrolizumab and Pemetrexed.In vivo (Athens, Greece)Article
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6 authors.
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Abstract
BACKGROUND/
aimElderly and very elderly patients with lung cancer have a comparably high risk of radiation pneumonitis (RP). Risk scores may help to identify these patients. We have developed a risk score for very elderly patients. PATIENTS AND
methodsNine characteristics were retrospectively investigated in 21 patients aged ≥80 years for associations with symptomatic RP. Characteristics achieving significance or showing a trend were incorporated in the score, which was compared to a previous tool without age limit.
resultsThe incidence of RP was 33.3% and significantly associated with mean lung dose (MLD) >20 Gy. Trends were found for MLD >13 Gy and cardiovascular disease. Based on these characteristics, three risk groups were formed (2-5, 7-9, and 12 points). RP rates were 0.0%, 44.4%, and 100.0%. Positive (PPV) and negative (NPV) predictive values were both 100.0%. When using the previous score, PPV and NPV were 71.4% and 100%.
conclusionGiven the limitations of this study, the newly developed age-specific risk score appears to be a valuable tool for identifying very elderly lung cancer patients at high or low risk of radiation pneumonitis, and may offer improved predictive performance over previously established models.
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