Evidence map›Paper›PMID 40876955›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2026

Noninvasive Monitoring of Inflammatory Processes by Myeloid Cell-Directed PET Tracers in an Experimental Severe Acute Respiratory Syndrome Coronavirus 2 Infection Model.

Marieke A Stammes, Gerrit Koopman, Teresa R Wagner, Bjoern Traenkle, Philipp D Kaiser, Petra Mooij, Nicole van der Werff, Roja Fidel Acar, Kinga P Böszörményi, Simone Blaess and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. SIRPα Immuno-PET Provides a Pan-Myeloid View of Immune Activity During COVID-19.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Marieke A StammesBiomedical Primate Research Centre, Rijswijk, The Netherlands; stammes@bprc.nl dominik.sonanini@med.uni-tuebingen.de.
Gerrit KoopmanBiomedical Primate Research Centre, Rijswijk, The Netherlands.
Teresa R WagnerNMI Natural and Medical Sciences Institute, University of Tübingen, Reutlingen, Germany.
Bjoern TraenkleNMI Natural and Medical Sciences Institute, University of Tübingen, Reutlingen, Germany.
Philipp D KaiserNMI Natural and Medical Sciences Institute, University of Tübingen, Reutlingen, Germany.
Petra MooijBiomedical Primate Research Centre, Rijswijk, The Netherlands.
Nicole van der WerffBiomedical Primate Research Centre, Rijswijk, The Netherlands.
Roja Fidel AcarBiomedical Primate Research Centre, Rijswijk, The Netherlands.
Kinga P BöszörményiBiomedical Primate Research Centre, Rijswijk, The Netherlands.
Simone BlaessNMI Natural and Medical Sciences Institute, University of Tübingen, Reutlingen, Germany.
Stefania PezzanaWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University Hospital Tübingen, Eberhard Karls University Tübingen, Tübingen, Germany.
Gerald ReischlWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University Hospital Tübingen, Eberhard Karls University Tübingen, Tübingen, Germany.
Andreas MaurerWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University Hospital Tübingen, Eberhard Karls University Tübingen, Tübingen, Germany.
Jan A M LangermansBiomedical Primate Research Centre, Rijswijk, The Netherlands.
Ulrich RothbauerCluster of Excellence iFIT 2180 "Image-Guided and Functionally Instructed Tumor Therapies," Eberhard Karls University, Tübingen, Germany.
Manfred KneillingWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University Hospital Tübingen, Eberhard Karls University Tübingen, Tübingen, Germany.
Dominik SonaniniNMI Natural and Medical Sciences Institute, University of Tübingen, Reutlingen, Germany; stammes@bprc.nl dominik.sonanini@med.uni-tuebingen.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Monitoring the presence and distribution of distinct immune cell populations is key in deciphering immunopathologic disease mechanisms. Considering the crucial role of myeloid cells in provoking hyperinflammatory responses associated with coronavirus disease 2019, a camelid-derived single-domain antibody specifically recognizing human signal-regulatory protein-α (SIRPα) as a biomarker for myeloid cells has been generated and radiolabeled with

Indexed as

COVID-19InflammationMyeloid CellsPositron-Emission TomographyAnimalsCopper RadioisotopesDisease Models, AnimalHumansMacaca fascicularisMalePositron Emission Tomography Computed TomographyRadioactive TracersSARS-CoV-2Copper-64Copper RadioisotopesRadioactive TracersCOVID-19monitoring of infectionnanobodyPET/CTSIRPαTSPO

Identifiers

PMID40876955
PMCPMC12766882

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.