Evidence map›Paper›PMID 40876929›Full record

ArticleLife science alliance2025

Enhanced locomotor recovery in mice lacking GlcNAc6ST1 and GlcNAc6ST4 following spinal cord injury.

Masayoshi Morozumi, Tomoya Ozaki, Kazuchika Nishitsuji, Yoshiko Takeda-Uchimura, Akiyuki Matsumoto, Sadayuki Ito, Shiro Imagama, Naoki Ishiguro, Hirokazu Yagi, Koichi Kato and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Masayoshi MorozumiDepartment of Biochemistry, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Tomoya OzakiDepartment of Biochemistry, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Kazuchika NishitsujiWakayama Medical University, Wakayama, Japan.ORCID 0000-0003-3056-8310
Yoshiko Takeda-UchimuraUniversity Lille, CNRS, UMR 8576-UGSF- Unité de Glycobiologie Structurale et Fonctionnelle, Lille, France.
Akiyuki MatsumotoDepartment of Biochemistry, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Sadayuki ItoDepartment of Biochemistry, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Shiro ImagamaDepartment of Orthopedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Naoki IshiguroDepartment of Orthopedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Hirokazu YagiGraduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan.ORCID 0000-0001-9296-0225
Koichi KatoGraduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan.ORCID 0000-0001-7187-9612
Tomoya O AkamaDepartment of Pharmacology, Kansai Medical University, Osaka, Japan.
Tomoki KosugiDepartment of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Shoichi MaruyamaDepartment of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Kenji KadomatsuDepartment of Biochemistry, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Steven D RosenDepartment of Anatomy, University of California, San Francisco, CA, USA.ORCID 0000-0002-6245-701X
Linda J Noble-HaeussleinDepartment of Neurosurgery, Physical Therapy and Rehabilitation Science, University of California, San Francisco, CA, USA.
Kenji UchimuraDepartment of Biochemistry, Nagoya University Graduate School of Medicine, Nagoya, Japan kenji.uchimura@univ-lille.fr.ORCID 0000-0003-3009-248X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal cord injury (SCI) damages neural circuits and triggers pro-inflammatory responses, resulting in locomotor impairment. The carbohydrate sulfotransferases GlcNAc6ST1 and GlcNAc6ST4 modulate the function of blood monocytes and microglia. However, their specific roles and enzymatic relationships in neuroinflammation and functional recovery after SCI remain unclear. In this study, we demonstrate that mice deficient in both GlcNAc6ST1 and GlcNAc6ST4 (DKO) exhibit improved locomotor recovery compared with mice with a single deficiency. DKO mice exhibit reduced levels of monocytes and activated macrophages/microglia at the injury site alongside increased serotonergic neural fibers, indicating enhanced neural plasticity. RNA sequencing reveals down-regulation of collagen I genes and up-regulation of genes encoding synaptic membrane components in the injured DKO spinal cord. In addition, GALAXY glycomic analysis shows an absence of GlcNAc-6-sulfated

Indexed as

Carbohydrate SulfotransferasesLocomotionRecovery of FunctionSpinal Cord InjuriesSulfotransferasesAnimalsDisease Models, AnimalFemaleMacrophagesMiceMice, Inbred C57BLMice, KnockoutMicrogliaMonocytesNeuronal PlasticitySpinal CordCarbohydrate SulfotransferasesSulfotransferases

Identifiers

PMID40876929
PMCPMC12394907

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.