Evidence map›Paper›PMID 40876509›Full record

Observational studyJournal of vascular and interventional radiology : JVIR2025

Association of Anesthesia Type and Vasoconstrictor Use with Intranodal Lymphangiography Duration: A Multicenter Retrospective Cohort Study.

Brian J Kinsman, Sara Smolinski-Zhao, Fran D Soljacic, Lingshan Liu, Matthew R Smith, Ariel L Mueller, Timothy T Houle, Katarina J Ruscic

Abstract readMulticenter StudyObservational StudyComparative Study
In one paragraph

Observational study in Journal of vascular and interventional radiology : JVIR, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Brian J KinsmanDepartment of Anesthesiology, Massachusetts General Hospital, Mass General Brigham, Harvard Medical School, Boston, Massachusetts.
Sara Smolinski-ZhaoDepartment of Interventional Radiology, Massachusetts General Hospital, Mass General Brigham, Harvard Medical School, Boston, Massachusetts.
Fran D SoljacicDepartment of Anesthesiology, Massachusetts General Hospital, Mass General Brigham, Harvard Medical School, Boston, Massachusetts.
Lingshan LiuDepartment of Anesthesiology, Massachusetts General Hospital, Mass General Brigham, Harvard Medical School, Boston, Massachusetts.
Matthew R SmithDepartment of Anesthesiology, Massachusetts General Hospital, Mass General Brigham, Harvard Medical School, Boston, Massachusetts.
Ariel L MuellerDepartment of Anesthesiology, Massachusetts General Hospital, Mass General Brigham, Harvard Medical School, Boston, Massachusetts.
Timothy T HouleDepartment of Anesthesiology, Massachusetts General Hospital, Mass General Brigham, Harvard Medical School, Boston, Massachusetts.
Katarina J RuscicDepartment of Anesthesiology, Massachusetts General Hospital, Mass General Brigham, Harvard Medical School, Boston, Massachusetts. Electronic address: kruscic@mgh.harvard.edu.

Funding

Research Training for AnesthetistsT32GM007592 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI STUART A FORMAN · 1985 to 2026
$11.8M
The Impact of Anesthetics on Lymphatic Vessel Contractility and Extracellular Fluid UptakeK08GM155886 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI Katarina J Ruscic · 2024 to 2026
$394k
NIGMS NIH HHS K08 GM155886NIGMS NIH HHS T32 GM007592
6 · The paper itself

Abstract

purposeTo investigate whether anesthesia type (sedation vs general anesthesia [GA]) or α MATERIALS AND

methodsThis retrospective observational study reviewed intranodal lymphangiography from 2 academic hospitals (2015-2022). A multiple linear regression model assessed the association of anesthesia type and vasoconstrictor administration with intralymphatic contrast agent transit time, controlled for confounders.

resultsA total of 147 lymphangiograms from 141 patients (median age, 64 years [interquartile range, 56-72 years]) were reviewed. Sedation (vs GA) was associated with 43% shorter log-transformed contrast agent transit time (βˆ = 1.43; 95% CI, 1.04-1.97; P = .029), reflecting a 13-minute faster median contrast agent transit time (absolute standardized difference, 0.44). Vasoconstrictor administration was not associated with contrast agent transit time (bolus administration, βˆ = 0.79 [95% CI, 0.53-1.18; P = .251]; infusion and bolus administration, βˆ = 0.89 [95% CI, 0.63-1.25; P = .495]). In addition to its association with increased contrast agent transit time, GA also added a median of 16 minutes (range, 11.0-22.3 minutes) of anesthesiology care time to cases.

conclusionsSedation (vs GA), but not vasoconstrictor administration, was associated with shorter contrast agent transit time and anesthesiology care time. This proof-of-concept clinical evidence that anesthesia may modulate lymphatic function sheds light on the lymphatic system as a collateral pharmacologic target of anesthetics.

Indexed as

Anesthesia, GeneralContrast MediaHypnotics and SedativesLymphographyProcedural SedationVasoconstrictor AgentsAgedFemaleHumansMaleMiddle AgedPredictive Value of TestsRetrospective StudiesTime FactorsContrast MediaHypnotics and SedativesVasoconstrictor Agents

Identifiers

PMID40876509
PMCPMC12570040

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.