Evidence map›Paper›PMID 40876460›Full record

ArticleNeuron2025

A posture subspace in the primary motor cortex.

Patrick J Marino, Lindsay Bahureksa, Carmen Fernández Fisac, Emily R Oby, Adam L Smoulder, Asma Motiwala, Alan D Degenhart, Erinn M Grigsby, Wilsaan M Joiner, Steven M Chase and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. The Importance of Synchrony in the Neural Control of Movement.bioRxiv : the preprint server for biology · 2026
    Article
  3. Object-directed action representations are componentially built in parietal cortex.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. A Generalist Intracortical Motor Decoder.bioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Patrick J MarinoDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15260, USA; Center for the Neural Basis of Cognition, Pittsburgh, PA 15213, USA. Electronic address: pmarino162@gmail.com.
Lindsay BahureksaCenter for the Neural Basis of Cognition, Pittsburgh, PA 15213, USA; Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
Carmen Fernández FisacCenter for the Neural Basis of Cognition, Pittsburgh, PA 15213, USA; Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
Emily R ObyDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15260, USA; Center for the Neural Basis of Cognition, Pittsburgh, PA 15213, USA; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L 3N6, Canada.
Adam L SmoulderCenter for the Neural Basis of Cognition, Pittsburgh, PA 15213, USA; Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
Asma MotiwalaCenter for the Neural Basis of Cognition, Pittsburgh, PA 15213, USA; Department of Electrical and Computer Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
Alan D DegenhartDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15260, USA; Center for the Neural Basis of Cognition, Pittsburgh, PA 15213, USA; Department of Electrical and Computer Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA; Starfish Neuroscience, Bellevue, WA 98004, USA.
Erinn M GrigsbyDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15260, USA; Center for the Neural Basis of Cognition, Pittsburgh, PA 15213, USA; Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15260, USA; Rehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Wilsaan M JoinerDepartment of Neurobiology, Physiology, and Behavior, University of California, Davis, Davis, CA 95616, USA.
Steven M ChaseCenter for the Neural Basis of Cognition, Pittsburgh, PA 15213, USA; Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA; Neuroscience Institute, Carnegie Mellon University, Pittsburgh, PA 15213, USA. Electronic address: schase@andrew.cmu.edu.
Byron M YuCenter for the Neural Basis of Cognition, Pittsburgh, PA 15213, USA; Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA; Department of Electrical and Computer Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA; Neuroscience Institute, Carnegie Mellon University, Pittsburgh, PA 15213, USA. Electronic address: byronyu@cmu.edu.
Aaron P BatistaDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15260, USA; Center for the Neural Basis of Cognition, Pittsburgh, PA 15213, USA. Electronic address: aaron.batista@pitt.edu.

Funding

Memory Formation in Motor CortexR01NS129584 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Aaron Paul Batista, Steven M Chase · 2022 to 2026
$2.8M
Interrogating and Perturbing Neural DynamicsR01NS105318 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Aaron Paul Batista, Steven M Chase · 2017 to 2026
$2.3M
NINDS NIH HHS R01 NS105318NINDS NIH HHS R01 NS129584
6 · The paper itself

Abstract

To generate movements, the brain must combine information about movement goal and body posture. The motor cortex (primary motor cortex [M1]) is a key node for the convergence of these information streams. How are posture and goal signals organized within M1's activity to permit the flexible generation of movement commands? To answer this question, we recorded M1 activity while monkeys performed a variety of tasks with the forearm in a range of postures. We found that posture- and goal-related components of neural population activity were separable and resided in nearly orthogonal subspaces. The posture subspace was stable across tasks. Within each task, neural trajectories for each goal had similar shapes across postures. Our results reveal a simpler organization of posture signals in M1 than previously recognized. The compartmentalization of posture and goal signals might allow the two to be flexibly combined in the service of our broad repertoire of actions.

Indexed as

Motor CortexPosturePsychomotor PerformanceAction PotentialsAnimalsBrain MappingMacaca mulattaMaleMovementNeuronsbrain-computer interfacebrain-machine interfacedimensionality reductionmotor cortexneural population dynamicspostureproprioceptionsensory-motor integration

Identifiers

PMID40876460
PMCPMC13295132

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.