Evidence map›Paper›PMID 40876243›Full record

ArticleInternational journal of obstetric anesthesia2025

The Obstetric Comorbidity Index (OB-CMI) and its association with ICU admission and length of hospital stay in pregnant patients with pulmonary hypertension: a retrospective cohort study (1996-2025).

S Ahmed, E Liu, B Eberhard, D Villela-Franyutti, K Gray, D Drzymalski, V Kovacheva

Abstract read
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Article in International journal of obstetric anesthesia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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7 authors.

S AhmedDepartment of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Anesthesiology, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
E LiuDepartment of Anesthesiology and Perioperative Medicine, Tufts Medicine, Boston, MA, USA.
B EberhardDepartment of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
D Villela-FranyuttiDepartment of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
K GrayDepartment of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA.
D DrzymalskiDepartment of Anesthesiology and Perioperative Medicine, Tufts Medicine, Boston, MA, USA.
V KovachevaDepartment of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: vkovacheva@bwh.harvard.edu.

Funding

Signatures of dysfunctional mitochondrial fatty acid oxidation that predispose to early-onset preeclampsiaK08HL146963 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI GRAY, KATHRYN JOHNSON · 2019 to 2023
$940k
Personalized Postpartum Hemorrhage Prediction Using Machine Learning And Polygenic Risk ScoresK08HL161326 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Vesela Kovacheva · 2022 to 2026
$842k
Clinical and functional follow-up of maternal and fetal preeclampsia genetic risk lociR03HL162756 · NHLBI · UNIVERSITY OF WASHINGTON · PI GRAY, KATHRYN JOHNSON · 2022 to 2023
$168k
NHLBI NIH HHS K08 HL146963NHLBI NIH HHS K08 HL146963-02S1NHLBI NIH HHS K08 HL161326NHLBI NIH HHS K08HL161326-01A1NHLBI NIH HHS R03 HL162756
6 · The paper itself

Abstract

backgroundPulmonary hypertension in pregnancy is associated with adverse pregnancy outcomes, such as prolonged hospitalization, intensive care unit (ICU) admission, and high maternal mortality. The Obstetric Comorbidity Index (OB-CMI) assesses maternal risk for these outcomes; however, its predictive power in patients with pulmonary hypertension remains unknown. This study evaluates maternal and neonatal outcomes in patients with pulmonary hypertension and examines whether a higher comorbidity burden is associated with longer hospitalization and ICU admission.

methodsA retrospective cohort study was conducted using electronic health records from Mass General Brigham and Tufts Medical Center (1996-July 2025). Patients with pulmonary hypertension and pregnancies beyond 20 weeks' gestation were identified using the International Classification of Disease-9/10 codes. Data were collected via manual chart review, and descriptive statistics and univariate regression analyses were performed (P < 0.05).

resultsSixty-five pregnancies among 61 patients were identified. The median maternal age was 32.9 (interquartile range 28.9-36.6) years. The maternal mortality rate was 3 %, with both deaths occurring before 2000. Most patients (56.9 %) had cesarean delivery under epidural anesthesia (69.2 %). Median OB-CMI was 9, and median hospitalization was 6 days. Pulmonary artery pressure was associated with prolonged hospitalization (P = 0.004) and ICU admission (P = 0.027). OB-CMI showed borderline association with ICU admission (P = 0.046), but not hospitalization duration (P = 0.580).

conclusionsIn patients with pulmonary hypertension, ICU admission and prolonged hospitalization were common and associated with pulmonary arterial pressure but not OB-CMI. Further studies are needed to develop scoring tools specific to pulmonary hypertension patients to improve risk assessment.

Indexed as

Hypertension, PulmonaryIntensive Care UnitsLength of StayPregnancy Complications, CardiovascularAdultCohort StudiesComorbidityFemaleHumansMaternal MortalityPregnancyPregnancy OutcomeRetrospective StudiesICU admissionObstetric Comorbidity IndexPregnancyPulmonary hypertensionRisk assessment

Identifiers

PMID40876243
PMCPMC12415544

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