Evidence map›Paper›PMID 40875741›Full record

ArticleJournal of vascular research2026

Vasomotion in Human Fingers.

Pekka Talke, Jonathan S Maltz, Marcus Talke, Mika Scheinin, Mohamed Kheir Diab

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Article in Journal of vascular research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Pekka TalkeDepartment of Anesthesia and Perioperative Medicine, University of California San Francisco, San Francisco, California, USA, talkep@gmail.com.
Jonathan S MaltzMolecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, California, USA.
Marcus TalkeValegos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Mika ScheininInstitute of Biomedicine, University of Turku, and Unit of Clinical Pharmacology, Turku University Hospital, Turku, Finland.
Mohamed Kheir DiabWillow Laboratories 121 Theory, Irvine, California, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

<p>Introduction: We describe methods by which vasomotion can be recorded in awake and anesthetized human subjects without significant interference from other spontaneous vascular oscillations.

methodsIn three separate studies, we used photoplethysmography (PPG) to record vasomotion in fingertips. In Study 1, we induced chemical sympathectomy in the studied hand of 11 awake subjects who received intravenous dexmedetomidine infusions. In Study 2, we administered four progressively increasing intravenous dexmedetomidine infusions to 16 awake volunteers. In Study 3, we recorded vasomotion simultaneously from 6 fingers of 7 patients who were under dexmedetomidine-based anesthesia. Five-minute epochs of PPG recordings that displayed slow vascular oscillations were analyzed for frequency and amplitude.

resultsIn Study 1, vasomotion frequencies were 0.025 ± 0.008 Hz. In Study 2, vasomotion frequencies were 0.033 ± 0.006 Hz, and 0.032 ± 0.008 Hz during the two highest dexmedetomidine infusion steps. In Study 3, vasomotion frequencies ranged from 0.020 to 0.037 Hz and were observed in all 6 fingers, with no synchrony between the six fingers.

conclusionThe vascular oscillations we observed without significant interference from other spontaneous oscillations are independent of neural activity (Study 1), local in nature (Study 3), and associated with alpha-2-adrenoceptor activation, consistent with known properties of vasomotion. </p>.

Indexed as

FingersPhotoplethysmographyVasoconstrictionAdrenergic alpha-2 Receptor AgonistsAdultDexmedetomidineFemaleHumansInfusions, IntravenousMaleMiddle AgedRegional Blood FlowSympathectomyTime FactorsWakefulnessYoung AdultAdrenergic alpha-2 Receptor AgonistsDexmedetomidineAlpha-2 adrenoceptor agonistMicrocirculationPhotoplethysmographySpontaneous vascular oscillationsVasomotion

Identifiers

PMID40875741
PMCPMC12503831

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