Evidence map›Paper›PMID 40875700›Full record

ArticleHormone research in paediatrics2025

Biomarkers in the Newborn with Fetal Growth Retardation and Early Impairment of Heart Function.

Olov Änghagen, Jan Engvall, Tomas Gottvall, Nina Nelson Follin, Eva Nylander, Petter Brodin, Tobias Rudholm Feldreich, Johan Ärnlöv, Peter Bang

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Article in Hormone research in paediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

9 authors.

Olov ÄnghagenCrown Princess Victoria's Child and Youth Hospital, Linköping University, Linköping, Sweden, olov.anghagen@liu.se.
Jan EngvallDepartment of Clinical Physiology in Linköping, Linköping University, Linköping, Sweden.
Tomas GottvallDepartment of Obstetrics and Gynecology, Linköping University, Linköping, Sweden.
Nina Nelson FollinCrown Princess Victoria's Child and Youth Hospital, Linköping University, Linköping, Sweden.
Eva NylanderDepartment of Clinical Physiology in Linköping, Linköping University, Linköping, Sweden.
Petter BrodinDepartment of Women's and Children's Health, Karolinska Institutet, Solna, Sweden.
Tobias Rudholm FeldreichSchool of Health and Welfare Dalarna University, Falun, Sweden.
Johan ÄrnlövSchool of Health and Welfare Dalarna University, Falun, Sweden.
Peter BangCrown Princess Victoria's Child and Youth Hospital, Linköping University, Linköping, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionChildren born with lower birth weight face an increased risk of developing cardiovascular disease later in life. We hypothesize that cardiovascular protein biomarkers in cord blood, associated with birth weight SDS and systolic cardiac function, may reveal mechanisms behind early programming of cardiovascular function.

methodsWe investigated the association between birth weight SDS and plasma levels of 184 circulating proteins determined by Proximity Extension Assay (PEA) in cord blood from 48 children. The birth weight-associated proteins were correlated with left ventricular longitudinal strain (LVLS) determined by echocardiography at birth and 3 months of age.

resultsWe identified seven cardiovascular protein biomarkers associated with birth weight SDS: stem cell factor, leptin, elafin, insulin-like growth factor-binding protein-1, follastatin, paraoxonase, and epithelial cell adhesion molecule (Ep-CAM). Among these, Ep-CAM significantly correlated with LVLS at 3 months of age.

conclusionPEA successfully identified both established and novel proteins associated with fetal growth and birth size, including one novel protein related to LVLS. This indicates that our approach is promising for uncovering biological pathways that may be involved in direct programming of cardiovascular function in children and affect the risk of cardiovascular disease in adulthood.

Indexed as

Birth weight biomarkersCardiovascular riskFetal growth retardationHeart functionLow birth weight

Identifiers

PMID40875700
PMCPMC12503826

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