Evidence map›Paper›PMID 40875505›Full record

ArticleCritical care explorations2025

Inter-rater Agreement of Richmond Agitation Sedation Scale Assessments in Adult Patients Receiving Mechanical Ventilation in the ICU: A Cross-Sectional Study.

Mikita Fuchita, Jack Pattee, David Le, Tien To, Carlos Mucharraz, Sara Knippa, Alexis Keyworth, Caitlin Blaine, Heidi Lindroth

Abstract read
In one paragraph

Article in Critical care explorations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. ComparativeFrontiers in pediatrics · 2026
    Article
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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mikita FuchitaDepartment of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO.ORCID 0000-0001-5976-7597
Jack PatteeDepartment of Biostatistics and Informatics, Center for Innovative Design & Analysis, Colorado School of Public Health, Aurora, CO.
David LeUniversity of Colorado School of Medicine, Aurora, CO.
Tien ToUniversity of Colorado School of Medicine, Aurora, CO.
Carlos MucharrazDepartment of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO.
Sara KnippaUCHealth University of Colorado Hospital, Aurora, CO.
Alexis KeyworthDepartment of Surgery, Division of Cardiothoracic Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO.
Caitlin BlaineDepartment of Surgery, Division of Cardiothoracic Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO.
Heidi LindrothDivision of Nursing Research, Department of Nursing, Mayo Clinic, Rochester, MN.

Funding

Anesthesiology Mentored Research TrainingT32GM135169 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI Susan L Ingram, Vesna Jevtovic-Todorovic · 2021 to 2026
$1.0M
Harnessing the Power of Technology to Transform Delirium Severity Measurement in the ICUK23AG076662 · NIA · MAYO CLINIC ROCHESTER · PI Heidi Lindroth · 2022 to 2026
$815k
Building a Sedation Minimization CultureK23HL177155 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Mikita Fuchita · 2025 to 2026
$362k
NHLBI NIH HHS K23 HL177155NIA NIH HHS K23 AG076662NIGMS NIH HHS T32 GM135169
6 · The paper itself

Abstract

importanceAccurate and reliable sedation assessment is crucial to improving patient outcomes in the ICU.

objectiveTo evaluate the inter-rater agreement and reliability of Richmond Agitation Sedation Scale (RASS) assessments between bedside nurses and trained investigators in patients receiving mechanical ventilation in the ICU. DESIGN, SETTING, AND

participantsAn assessor triad, comprising an ICU nurse providing direct patient care and two trained investigators, simultaneously performed RASS assessments during 79 encounters with 62 unique patients receiving mechanical ventilation at two ICUs at a tertiary care academic hospital in Colorado. A total of 58 nurses participated in the study. MAIN OUTCOMES AND MEASURES: The inter-rater reliability of RASS assessments was evaluated with the intraclass correlation coefficient (ICC) and weighted kappa (κ), and inter-rater agreement was evaluated with percentage agreement and Bland-Altman analysis.

resultsAcute respiratory failure (55%) and altered mental status (21%) were the most common reasons for mechanical ventilation. Most patients were receiving one (interquartile range, 0.5-2) continuous sedative during the assessment. The inter-rater reliability of RASS assessments between the nurses and investigators (ICC, 0.728-0.779; weighted κ, 0.62-0.63) was lower than between the two investigators (ICC, 0.891; weighted κ, 0.80). The assessor triad agreed on the same RASS values in only 35% of observations. The average differences in RASS were greater between the investigators and nurses, ranging from -0.658 to -0.544, compared with 0.114 between the two investigators. Compared with the mean of the two investigators, RASS values recorded by nurses were more likely to be higher (52% of observations), indicating a lighter sedation level. In 16% of observations, at least one assessor commented on uncertainty or ambiguity with the RASS. CONCLUSIONS AND RELEVANCE: The inter-rater reliability of RASS assessments was high. However, we observed variations in the degree of agreement by assessor category. Further studies are necessary to explore how factors such as assessor characteristics, ICU environment, and patient conditions influence the inter-rater agreement of the RASS in contemporary ICU practices.

Indexed as

Intensive Care UnitsPsychomotor AgitationRespiration, ArtificialAdultAgedColoradoCross-Sectional StudiesFemaleHumansHypnotics and SedativesMaleMiddle AgedObserver VariationReproducibility of ResultsHypnotics and Sedativeshealth services researchmechanical ventilationnursing carepsychomotor agitationquality improvementsedation

Identifiers

PMID40875505
PMCPMC12398364

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.