Evidence map›Paper›PMID 40875335›Full record

ArticleAmerican journal of physiology. Renal physiology2025

KCC3 is not required for the distal convoluted tubule response to reduced dietary potassium intake.

Masa-Ki Inoue, Alina Yu, Mohammed Zubaerul Ferdaus, Yahua Zhang, Xiao-Tong Su, Fabian Bock, Juan Pablo Arroyo, Kayla Y Cho, David H Ellison, Ming-Zhi Zhang and 3 more

Abstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Masa-Ki InoueDivision of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States.ORCID 0009-0007-3482-8710
Alina YuDivision of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States.
Mohammed Zubaerul FerdausDepartment of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee, United States.ORCID 0000-0002-4860-5506
Yahua ZhangDivision of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States.
Xiao-Tong SuDivision of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon, United States.ORCID 0000-0001-8121-8105
Fabian BockDivision of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States.ORCID 0000-0002-0788-2945
Juan Pablo ArroyoDivision of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States.ORCID 0000-0002-5992-5011
Kayla Y ChoDivision of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States.
David H EllisonDivision of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon, United States.ORCID 0000-0003-2915-265X
Ming-Zhi ZhangDivision of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States.
Raymond C HarrisDivision of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States.
Eric DelpireDepartment of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee, United States.ORCID 0000-0002-3702-1599
Andrew S TerkerDivision of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States.ORCID 0000-0003-1498-9043

Funding

WNK-SPAK signaling in the Distal NephronR01DK093501 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Eric J Delpire, Paul A Welling · 2012 to 2026
$12.1M
The Role of the EGF Receptor in Acute and Chronic Renal InjuryR01DK051265 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RAYMOND C. HARRIS, Mingzhi Zhang · 1997 to 2026
$10.1M
The role of the innate immune cell cyclooxygenase/prostaglandin system in blood pressureregulationR01DK062794 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RAYMOND C. HARRIS, Mingzhi Zhang · 2003 to 2026
$9.4M
The Role of renal macrophages in recovery from renal injuryR01DK095785 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RAYMOND C. HARRIS, Mingzhi Zhang · 2013 to 2026
$6.7M
Vanderbilt O'Brien Kidney Center - Core D - Clinical and Translational CoreP30DK114809 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HARRIS, RAYMOND C. · 2017 to 2021
$5.9M
VANDERBILT NEPHROLOGY TRAINING PROGRAMT32DK007569 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HARRIS, RAYMOND C., IKIZLER, TALAT ALP · 1988 to 2024
$5.8M
Innovative therapeutic approaches to treat chronic kidney diseaseDP5OD033412 · OD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI TERKER, ANDREW S. · 2022 to 2025
$2.2M
Understanding the physiology and pathophysiology of kidney-derived vasopressinK08DK135931 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Juan Pablo Arroyo Ornelas · 2023 to 2026
$696k
Rac1 and the actin cytoskeleton in renal tubular repairK08DK134879 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Fabian Maximilian Bock · 2023 to 2026
$636k
HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) DP5-OD033412NIDDK NIH HHS K08 DK134879NIDDK NIH HHS K08 DK135931NIDDK NIH HHS P30 DK114809NIDDK NIH HHS R01 DK051265NIDDK NIH HHS R01 DK062794NIDDK NIH HHS R01 DK093501NIDDK NIH HHS R01 DK095785NIDDK NIH HHS T32 DK007569NIH HHS DP5 OD033412
6 · The paper itself

Abstract

The distal convoluted tubule (DCT) plays a crucial role in potassium (K

Indexed as

K Cl- CotransportersKidney Tubules, DistalPotassium, DietarySodium Chloride SymportersAnimalsGene Expression RegulationMaleMiceMice, KnockoutK Cl- CotransportersPotassium, DietarySlc12a6 protein, mouseSodium Chloride SymporterschlorideDCTKCCNCCpotassium

Identifiers

PMID40875335
PMCPMC12870740

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.