Evidence map›Paper›PMID 40875266›Full record

ArticleRadiation protection dosimetry2025

Short and long-term effects on the thyroid proteome after 131I exposure.

Klara Insulander Björk, Britta Langen, Anja Schroff, Emman Shubbar, Khalil Helou, Johan Spetz, Eva Forssell-Aronsson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiation protection dosimetry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Klara Insulander BjörkDepartment of Medical Radiation Sciences, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, SE 413 45 Gothenburg, Sweden.ORCID 0000-0002-8092-0389
Britta LangenDepartment of Medical Radiation Sciences, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, SE 413 45 Gothenburg, Sweden.
Anja SchroffDepartment of Medical Radiation Sciences, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, SE 413 45 Gothenburg, Sweden.
Emman ShubbarDepartment of Medical Radiation Sciences, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, SE 413 45 Gothenburg, Sweden.
Khalil HelouSahlgrenska Centre for Cancer Research, Sahlgrenska Academy, University of Gothenburg, SE 405 30 Gothenburg, Sweden.
Johan SpetzDepartment of Medical Radiation Sciences, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, SE 413 45 Gothenburg, Sweden.
Eva Forssell-AronssonDepartment of Medical Radiation Sciences, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, SE 413 45 Gothenburg, Sweden.ORCID 0000-0002-7558-4368

Funding

Swedish Cancer Society 23 2975Swedish Research Council 2021-02636Swedish state under the agreement between the Swedish government and the county councils-the ALF-agreement ALFGBG-966074
6 · The paper itself

Abstract

131I is recognised, both for its significance in nuclear medicine, and for its association with a rise in paediatric but not adult thyroid cancer cases following the Chornobyl accident. However, the detailed radiobiological mechanisms underlying 131I effects on the thyroid remain unknown to date. In the present study, 1 kBq or 100 kBq 131I was administered to mice that were euthanised after 48 h, 3 weeks or 6 months. Thyroid glands were surgically removed, and proteins were extracted and analysed by tandem mass spectrometry. On a group-level, the results showed few alterations in protein abundance, mainly linked to RNA metabolism and DNA damage response. However, individual analysis of protein abundance changes in each animal showed distinct findings suggesting inhibited proliferation in a few individuals across various exposure levels and time points. Future studies should involve larger animal groups to better assess the frequency and variability of proteomic radiation responses.

Indexed as

Iodine RadioisotopesProteomeThyroid GlandAnimalsDose-Response Relationship, RadiationFemaleMaleMiceProteomicsTandem Mass SpectrometryIodine-131Iodine RadioisotopesProteome

Identifiers

PMID40875266
PMCPMC12392893

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.