Evidence map›Paper›PMID 40875264›Full record

ArticleRadiation protection dosimetry2025

Early proteomic response in thyroid gland after 131I administration in female Balb/c mice.

Nils Rudqvist, Johan Spetz, Emil Schüler, Toshima Z Parris, Britta Langen, Carina Sihlbom Wallem, Khalil Helou, Eva Forssell-Aronsson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiation protection dosimetry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nils RudqvistDepartment of Medical Radiation Sciences, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, SE-413 45 Gothenburg, Sweden.
Johan SpetzDepartment of Medical Radiation Sciences, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, SE-413 45 Gothenburg, Sweden.
Emil SchülerDepartment of Medical Radiation Sciences, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, SE-413 45 Gothenburg, Sweden.
Toshima Z ParrisSahlgrenska Cancer Center, Sahlgrenska Academy, University of Gothenburg, Box 425, SE-405 30 Gothenburg, Sweden.
Britta LangenDepartment of Medical Radiation Sciences, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, SE-413 45 Gothenburg, Sweden.
Carina Sihlbom WallemSambio Core Facilities, Sahlgrenska Academy, University of Gothenburg, Box 413, SE-405 30 Gothenburg, Sweden.
Khalil HelouSahlgrenska Cancer Center, Sahlgrenska Academy, University of Gothenburg, Box 425, SE-405 30 Gothenburg, Sweden.
Eva Forssell-AronssonDepartment of Medical Radiation Sciences, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, SE-413 45 Gothenburg, Sweden.ORCID 0000-0002-7558-4368

Funding

Swedish Cancer Society 20 1293Swedish government and the county councils-the ALF-agreement ALFGBG-966074Swedish Research Council 2021-02636
6 · The paper itself

Abstract

131I (iodide) accumulates in the thyroid and may affect thyroid tissue. Mechanisms behind such effects are not known. The aim was to investigate early changes in protein expression in thyroid and plasma from mice injected with 131I as iodide. Female Balb/c nude mice were i.v. injected with 0 or 490 kBq 131I and killed after 24 h. Thyroid and blood samples were collected from each animal. Protein levels were determined by mass spectrometry. Data are available via ProteomeXchange with identifier PXD062861. Altogether, 17 and 20 proteins showed statistically significant altered levels in thyroid gland and plasma, respectively, after 131I exposure. Most of these proteins had decreased and increased levels in thyroid and plasma, respectively. Few of them were previously proposed radiation responsive proteins. Functional annotation suggests impact on haematopoiesis, reduced oxygen levels, and hypothyroidism. The role of CHIA and PGAM2 in radiation-induced response should be further examined, together with identification and validation of biomarkers of 131I exposure.

Indexed as

Iodine RadioisotopesProteomeProteomicsThyroid GlandAnimalsBiomarkersFemaleMiceMice, Inbred BALB CMice, NudeBiomarkersIodine-131Iodine RadioisotopesProteome

Identifiers

PMID40875264
PMCPMC12392886

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.