Evidence map›Paper›PMID 40875262›Full record

ArticleRadiation protection dosimetry2025

Early apoptotic response in kidney after 177Lu-octreotate administration with or without potential radioprotector α1-microglobulin.

Charlotte Ytterbrink, Klara Simonsson, Emman Shubbar, Magnus Gram, Khalil Helou, Eva Forssell-Aronsson

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In one paragraph

Article in Radiation protection dosimetry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Charlotte YtterbrinkDepartment of Medical Radiation Sciences, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, SE-413 45 Gothenburg, Sweden.
Klara SimonssonDepartment of Medical Radiation Sciences, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, SE-413 45 Gothenburg, Sweden.
Emman ShubbarDepartment of Medical Radiation Sciences, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, SE-413 45 Gothenburg, Sweden.
Magnus GramPediatrics, Department of Clinical Sciences Lund, Lund University, SE-221 85 Lund, Sweden.
Khalil HelouSahlgrenska Center for Cancer Research, Sahlgrenska Academy at the University of Gothenburg, Box 425, SE-405 30 Gothenburg, Sweden.
Eva Forssell-AronssonDepartment of Medical Radiation Sciences, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, SE-413 45 Gothenburg, Sweden.

Funding

Swedish Cancer Society 23 2975Swedish Research Council 2021-02636
6 · The paper itself

Abstract

The antioxidant α1-microglobulin (A1M) has been suggested as kidney protector during 177Lu-octreotate treatment. The aim of this work was to evaluate apoptotic-related transcript expression in kidney cortex and medulla following injection of 177Lu-octreotate and/or A1M. Mice were injected with 177Lu-octreotate, A1M, or 177Lu-octreotate + A1M. Control groups received PBS or vehicle solution. Animals were killed after 24 hours or 7 d. mRNA was isolated from kidney medulla and cortex. Expression of 84 apoptosis-related genes was assessed by q-PCR. Gene expression profiles in kidney cortex were generally similar in the 177Lu-octreotate and 177Lu-octreotate + A1M groups. This was also seen in kidney medulla at 24 hours, but at 7 d anti-apoptotic response of A1M was observed. Altogether, 177Lu-octreotate exposure induced pro-apoptotic response (e.g. Apaf1, Bax, and Tnfrsf10b genes) in kidney medulla and cortex. A1M co-administration did not inhibit pro-apoptotic response in kidney cortex, while A1M initiated pro-survival mechanisms in kidney medulla.

Indexed as

Alpha-GlobulinsApoptosisKidneyLutetiumOctreotideRadiation-Protective AgentsAnimalsKidney CortexMaleMiceRadioisotopes177Lu-octreotatealpha-1-microglobulinAlpha-GlobulinsLutetiumOctreotideRadiation-Protective AgentsRadioisotopes

Identifiers

PMID40875262
PMCPMC12392902

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.