Evidence map›Paper›PMID 40875095›Full record

ArticleClinical pharmacology and therapeutics2026

Impact of Race on Profiles of Platelet Reactivity and Clinical Outcomes in Clopidogrel-Treated Participants.

Luis Ortega-Paz, Cameron D Thomas, Claudio Laudani, Salvatore Giordano, Francesco Franchi, Kayla R Tunehag, Fabiana Rollini, Selina Durukan, Joseph S Rossi, Maryam Farahmandsadr and 8 more

Abstract read
In one paragraph

Article in Clinical pharmacology and therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Luis Ortega-PazDivision of Cardiology, University of Florida College of Medicine, Jacksonville, Florida, USA.ORCID 0000-0002-9567-3253
Cameron D ThomasDepartment of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine, College of Pharmacy, University of Florida, Gainesville, Florida, USA.ORCID 0000-0001-5040-2313
Claudio LaudaniDivision of Cardiology, University of Florida College of Medicine, Jacksonville, Florida, USA.ORCID 0000-0001-5467-7402
Salvatore GiordanoDivision of Cardiology, University of Florida College of Medicine, Jacksonville, Florida, USA.ORCID 0000-0002-2591-6010
Francesco FranchiDivision of Cardiology, University of Florida College of Medicine, Jacksonville, Florida, USA.ORCID 0000-0001-8503-5736
Kayla R TunehagDivision of Cardiology and McAllister Heart Institute, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA.ORCID 0000-0003-3442-7347
Fabiana RolliniDivision of Cardiology, University of Florida College of Medicine, Jacksonville, Florida, USA.
Selina DurukanDivision of Cardiology, University of Florida College of Medicine, Jacksonville, Florida, USA.ORCID 0009-0005-7811-9241
Joseph S RossiDivision of Cardiology and McAllister Heart Institute, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA.ORCID 0009-0008-7209-4348
Maryam FarahmandsadrDivision of Cardiology, University of Florida College of Medicine, Jacksonville, Florida, USA.ORCID 0000-0003-1890-5839
George A StoufferDivision of Cardiology and McAllister Heart Institute, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA.ORCID 0000-0001-8208-8998
Latonya BeenDivision of Cardiology, University of Florida College of Medicine, Jacksonville, Florida, USA.ORCID 0000-0002-3366-6998
Ellen C KeeleyDivision of Cardiovascular Medicine College of Medicine, University of Florida, Gainesville, Florida, USA.ORCID 0000-0001-5266-6662
Julio D DuarteDepartment of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine, College of Pharmacy, University of Florida, Gainesville, Florida, USA.ORCID 0000-0001-9766-4038
Amber L BeitelsheesUniversity of Maryland School of Medicine, Department of Medicine and Program for Personalized and Genomic Medicine, Baltimore, Maryland, USA.ORCID 0000-0003-0958-7197
Craig R LeeDivision of Cardiology and McAllister Heart Institute, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA.ORCID 0000-0003-3595-5301
Larisa H CavallariDepartment of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine, College of Pharmacy, University of Florida, Gainesville, Florida, USA.ORCID 0000-0002-7184-5292
Dominick J AngiolilloDivision of Cardiology, University of Florida College of Medicine, Jacksonville, Florida, USA.ORCID 0000-0001-8451-2131

Funding

Re-Entry Supplement: Investigation of Oral Microbial Enzymes for the Detection and Treatment of Periodontal DiseaseUL1TR002489 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, SHAHEEN, NICHOLAS J · 2018 to 2022
$48.6M
North Carolina Translational and Clinical Sciences Institute (NC TraCS)UM1TR004406 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NICHOLAS J SHAHEEN · 2023 to 2026
$37.5M
Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2M
Sparking Advancements in Genomic MedicineU01HG007269 · NHGRI · UNIVERSITY OF FLORIDA · PI CAVALLARI, LARISA HUMMA, JOHNSON, JULIE A. · 2013 to 2024
$17.0M
Precision antiplatelet therapy after percutaneous coronary interventionR01HL149752 · NHLBI · UNIVERSITY OF FLORIDA · PI CAVALLARI, LARISA HUMMA, LEE, CRAIG R · 2020 to 2024
$3.5M
NCATS NIH HHS UL1 TR001427NCATS NIH HHS UL1 TR002489NCATS NIH HHS UM1 TR004406NHGRI NIH HHS U01 HG007269NHLBI NIH HHS R01 HL149752
6 · The paper itself

Abstract

Black individuals undergoing percutaneous coronary intervention (PCI) experience higher rates of major adverse cardiovascular events (MACE) than non-Black individuals. This study assessed the racial differences in platelet reactivity and clinical outcomes among clopidogrel-treated participants. Two cohorts were analyzed. The pharmacodynamic (PD) cohort involved patients with atherosclerotic cardiovascular disease on maintenance clopidogrel therapy undergoing platelet function testing. The primary outcome was high platelet reactivity (HPR, i.e., P2Y

Indexed as

Black or African AmericanBlood PlateletsClopidogrelPercutaneous Coronary InterventionPlatelet Aggregation InhibitorsAgedCytochrome P-450 CYP2C19FemaleHemorrhageHumansMaleMiddle AgedPlatelet Function TestsReceptors, Purinergic P2Y12Treatment OutcomeWhiteClopidogrelCYP2C19 protein, humanCytochrome P-450 CYP2C19P2RY12 protein, humanPlatelet Aggregation InhibitorsReceptors, Purinergic P2Y12

Identifiers

PMID40875095
PMCPMC12450309

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.