Evidence map›Paper›PMID 40875051›Full record

ArticleExperimental brain research2025

Motor planning stage of gait initiation: effects of aging, Parkinson's disease, and associations with cognitive function.

Galia Shaham, Irina Galperin, Amit Salomon, Eran Gazit, Aron S Buchman, Nir Giladi, James K Richardson, Jeffrey M Hausdorff

Abstract read
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In one paragraph

Article in Experimental brain research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Galia ShahamCenter for the Study of Movement, Cognition and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv, Israel.
Irina GalperinCenter for the Study of Movement, Cognition and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv, Israel.
Amit SalomonCenter for the Study of Movement, Cognition and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv, Israel.
Eran GazitCenter for the Study of Movement, Cognition and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv, Israel.
Aron S BuchmanRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Nir GiladiCenter for the Study of Movement, Cognition and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv, Israel.
James K RichardsonDepartment of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI, USA.
Jeffrey M HausdorffCenter for the Study of Movement, Cognition and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv, Israel. jeffh@tlvmc.gov.il.ORCID http://orcid.org/0000-0002-1608-0776

Funding

Impaired Gait in Older Adults: Pathologies of Alzheimer's disease and Related DisordersR01AG056352 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BUCHMAN, ARON S · 2017 to 2021
$3.5M
Thinking about walking: Can digital phenotyping of mobility improve the prediction of Alzheimer's dementia and inform on the pathologies and proteins contributing to this association?R01AG079133 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI ARON S BUCHMAN · 2022 to 2026
$3.5M
NIA NIH HHS R01 AG056352NIA NIH HHS R01 AG079133
6 · The paper itself

Abstract

The response to a request to walk involves a motor planning phase followed by an execution phase. The initial phase of gait initiation, specifically the time to anticipatory postural adjustment (APA), can be viewed as a form of reaction time. However, it is not clear how to characterize the cognitive processes involved in this stage. To address this question, time-to-APA, simple and complex upper limb visuomotor reaction time (SRT, CRT), cognitive, and motor performance were evaluated in 27 people with Parkinson's disease (PD), 31 older adults (OA), and 34 young adults (YA). Our results showed that time-to-APA was significantly longer than SRT in all three groups (p < 0.001), indicating a more complex cognitive process. In YA, time-to-APA was significantly shorter than CRT (p < 0.001). In the OA and PD, time-to-APA was not significantly different from CRT. Mixed-effects analysis showed significant time (p < 0.001), group (p = 0.037), and group × time interaction effects (p = 0.002). Among all subjects, time-to-APA, but not APA duration, was associated with the Color-Trails Test (part B: r

Indexed as

AgingCognitionGaitParkinson DiseasePsychomotor PerformanceAdultAgedFemaleHumansMaleMiddle AgedReaction TimeYoung AdultAgingCognitionElderlyGait initiationParkinson’s diseaseReaction timeResponse inhibition

Identifiers

PMID40875051
PMCPMC12394281

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.