ArticleArchives of microbiology2025
DNA gyrase-inhibitory antimicrobial anthraquinone from the endophytic Sordariomycetes fungus Diaporthe perseae.
Article in Archives of microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Dimeric Anthraquinone Rugulosin A Induces Apoptosis in Lung Adenocarcinoma and Targets PI3K/AKT/MAPK PathwaysACS omega · 2026Article
- Novel Metabolites ofJournal of fungi (Basel, Switzerland) · 2026Article
- A comprehensive review on bacterial endophytic secondary metabolites: a road map from crude extract to lead molecule production.Frontiers in pharmacology · 2026Review
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Authors and funding
7 authors.
Funding
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Abstract
Fungi of the order Diaporthales are prolific sources of antimicrobial secondary metabolites. In this paper, we describe antimicrobial and antituberculosis anthraquinones (AQs) from Diaporthe perseae, an endophytic fungus isolated and identified from the endemic Philippine medicinal plant Uvaria alba (Annonaceae). Large-scale rice fermentation of D. perseae yielded an ethyl acetate extract which was subjected to a series of chromatographic purification to yield three compounds. Spectroscopic analyses allowed the identification of the anthraquinone compounds citreorosein (1), skyrin (2), and rugulosin A (3). AQs 1 and 3 showed broad-spectrum against Gram-positive bacteria (Micrococcus luteus, Bacillus subtilis, and Staphylococcus aureus) (MIC = 1.0-2.0 µg/mL), however only 3 demonstrated strong inhibition against Gram-negative bacterial strains (Escherichia coli, Pseudomonas aeruginosa, and Chromobacterium violaceum) and non-TB mycobacteria (Mycobacterium smegmatis) (MIC = 8.25-66.0 µg/mL). AQ 3 also exhibited inhibition against both M. tuberculosis (Mtb) H
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