ArticleBioprocess and biosystems engineering2025
The use of dimethyl sulfoxide (DMSO) to increase PET microbial degradation by Yarrowia lipolytica IMUFRJ 50682.
Article in Bioprocess and biosystems engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Yeast-Mediated Plastic Biodegradation.International journal of molecular sciences · 2026Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Yarrowia lipolytica has been studied for poly (ethylene terephthalate) (PET) depolymerization, but the slow kinetics must be improved for large-scale applications. Here, dimethyl sulfoxide (DMSO) was added to a medium containing post-consumer PET (PC-PET) or the monomers terephthalic acid (TPA), bis(hydroxy-ethylene) terephthalate (BHET), and methyl-2-hydroxy ethylene terephthalate (MHET) to increase its solubility and improve depolymerization. The MIC test indicated 5% of DMSO as the maximum non-toxic concentration for Y. lipolytica cultivation. Cell viability on yeast nitrogen-based (YNB) medium was higher with MHET (94%). Cell growth in YNB medium and PC-PET was only detected with DMSO. When PC-PET was used as an additional carbon source, cell growth was 40% higher in the presence of DMSO (10.7 g/L), exhibiting increased adhesion of cells to PET (20%). Also, the highest extracellular lipase activity (370 U/L) was found with DMSO and PC-PET in flasks. In a bioreactor, higher cell growth (32.6 g/L) and lipase activity (7531 U/L) were obtained in YP*D medium with PC-PET and DMSO. During cultivation in this medium, TPA, MHET, and BHET were detected, demonstrating PET depolymerization along Y. lipolytica growth with DMSO. These results show that DMSO contributes to PET depolymerization by Y. lipolytica, increasing cell concentration, adhesion to PET particles, and enzyme production.
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Identifiers
40874996What OpenQuestion holds
Registered trials
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