Evidence map›Paper›PMID 40874884›Full record

ArticleJACC. Advances2025

Advanced Echocardiographic Assessment Predicts 1-Year Mortality in Critically Ill Patients With Pulmonary Arterial Hypertension.

Hoda Mombeini, Vivek P Jani, Jasmine Malhi, Ryan Osgueritchian, Garrett Goldin, Kaidong Wang, Mario Naranjo, Valentina Mercurio, Hussein Hassan, Steve Hsu and 5 more

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Article in JACC. Advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Hoda MombeiniDivision of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA.
Vivek P JaniDivision of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA.
Jasmine MalhiDivision of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA.
Ryan OsgueritchianDivision of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA.
Garrett GoldinDivision of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA.
Kaidong WangDivision of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA.
Mario NaranjoDivision of Pulmonary Critical Care Medicine, Temple University, Philadelphia, Pennsylvania, USA.
Valentina MercurioDepartment of Translational Medical Sciences, Federico II University, Naples, Italy.
Hussein HassanDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Steve HsuDivision of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA.
Catherine E SimpsonDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Todd M KolbDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Stephen C MathaiDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Paul M HassounDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Monica MukherjeeDivision of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA. Electronic address: mmukher2@jhu.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDespite advancements in diagnosing and managing pulmonary arterial hypertension (PAH), critically ill patients with PAH experience high mortality and current risk scores offer limited utility for risk stratification.

objectivesThe purpose of this study was to evaluate whether echo-derived right heart metrics improve risk prediction for in-hospital and 1-year mortality in critically ill PAH patients.

methodsWe analyzed PAH patients admitted to the intensive care unit from January 2010 to December 2020, with follow-up through January 2025. Echocardiographic assessments included right atrium (RA) area and phasic function, tricuspid annular plane systolic excursion (TAPSE), fractional area change, regional and global right ventricular (RV) free wall strain (RVFWS), and RV to pulmonary artery (PA) systolic pressure (PASP) coupling ratios. Cox regression evaluated in-hospital and 1-year mortality, and a random survival forest (RSF) model identified nonlinear predictors of 1-year mortality.

resultsOf 102 patients, 77 (20 idiopathic PAH, 45 connective tissue disease-associated PAH, 12 other subtypes) had adequate echocardiograms. Cox regression revealed significant associations between in-hospital mortality and TAPSE and RA enlargement. Impaired TAPSE, RVFWS

conclusionsIn critically ill PAH patients, echocardiographic markers were independently associated with mortality. A novel RSF model identified key variables for risk prediction, emphasizing the value of comprehensive echocardiographic assessment in this high-risk population.

Indexed as

echocardiographyintensive caremortalitypulmonary arterial hypertensionright ventricle

Identifiers

PMID40874884
PMCPMC12541211

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.