Evidence map›Paper›PMID 40874883›Full record

ArticleJACC. Advances2025

Fever in Myocardial Infarction-Related Cardiogenic Shock.

Matthew Pierce, Abduljabar Adi, Rohit Jain, Ahmed Calvo, Satvinder Guru, Shuojohn Li, Ramsis Ramsis, Moein Bayat Mokhtari, Dechen Samdrup, Sapana Yonghang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Matthew PierceNorthwell Health, New Hyde Park, New York, USA; North Shore University Hospital, Manhasset, New York, USA.
Abduljabar AdiNorthwell Health, New Hyde Park, New York, USA; The Feinstein Institutes for Medical Research, Manhasset, New York, USA; Lenox Hill Hospital, New York, New York, USA.
Rohit JainNorthwell Health, New Hyde Park, New York, USA; Lenox Hill Hospital, New York, New York, USA.
Ahmed CalvoNorthwell Health, New Hyde Park, New York, USA; Lenox Hill Hospital, New York, New York, USA.
Satvinder GuruNorthwell Health, New Hyde Park, New York, USA; Lenox Hill Hospital, New York, New York, USA.
Shuojohn LiNorthwell Health, New Hyde Park, New York, USA; North Shore University Hospital, Manhasset, New York, USA.
Ramsis RamsisNorthwell Health, New Hyde Park, New York, USA; Lenox Hill Hospital, New York, New York, USA.
Moein Bayat MokhtariNorthwell Health, New Hyde Park, New York, USA; Lenox Hill Hospital, New York, New York, USA.
Dechen SamdrupNorthwell Health, New Hyde Park, New York, USA; Lenox Hill Hospital, New York, New York, USA.
Sapana YonghangNorthwell Health, New Hyde Park, New York, USA; Lenox Hill Hospital, New York, New York, USA.
Joshua RoubinNorthwell Health, New Hyde Park, New York, USA; The Feinstein Institutes for Medical Research, Manhasset, New York, USA; Lenox Hill Hospital, New York, New York, USA.
Atul D BaliNorthwell Health, New Hyde Park, New York, USA; Lenox Hill Hospital, New York, New York, USA.
Joao D FontesNorthwell Health, New Hyde Park, New York, USA; Lenox Hill Hospital, New York, New York, USA.
Matthew GriffinNorthwell Health, New Hyde Park, New York, USA; North Shore University Hospital, Manhasset, New York, USA.
Miguel Alvarez VillelaNorthwell Health, New Hyde Park, New York, USA; Lenox Hill Hospital, New York, New York, USA. Electronic address: malvarezvill@northwell.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe role of fever in acute myocardial infarction-related cardiogenic shock (AMI-CS) in the contemporary era is not well described.

objectivesThe aim of the study was to describe the epidemiology of fever in AMI-CS and its impact on clinical outcomes.

methodsAmong all AMI-CS patients in the Northwell-Shock registry (n = 1,372), fever was identified via ≥2 temperatures ≥38.0 °C or one ≥38.3 °C. Characteristics, management, and outcomes were compared between patients with and without fever.

resultsFever occurred in 40% of patients at a median of 2 days [0-6] after admission. Patients with fever were younger, more often male, and had higher shock severity, receiving more invasive treatment. Febrile patients received more antibiotics (84% vs 42%; P < 0.001), yet only 21% had positive microbial cultures. Early fever (<72 hours) was associated with a lower rate of positive cultures (13% vs 24%; P = 0.002). In-hospital mortality was similar between the groups (30% vs 31%; P = 0.78), but patients with fever had longer hospital stays (19 days vs 9 days; P < 0.001) and more discharges to skilled nursing facilities (49% vs 36%; P < 0.001). On multivariable logistic regression, female sex (OR: 1.9; P = 0.001), non-ST-segment elevation myocardial infarction etiology (OR = 1.5; P = 0.047), mechanical ventilation (OR: 2.1; P < 0.001), and acute dialysis (OR: 1.6; P = 0.040) were associated with positive cultures in febrile patients.

conclusionsFever in AMI-CS is common and is associated with greater illness severity but seems to be noninfectious in most cases. Further research should focus on improving antibiotic use in this population.

Indexed as

antibioticcardiogenic shockculturefeverinfectionmyocardial infarction

Identifiers

PMID40874883
PMCPMC12541219

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.