ArticleInvestigative ophthalmology & visual science2025
Retinal Vessel Changes in Geographic Atrophy in AMD: Insights From Imaging and Histology.
Article in Investigative ophthalmology & visual science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Purpose: The purpose of this study was to investigate retinal vascular changes in geographic atrophy (GA) secondary to age-related macular degeneration (AMD) using swept-source optical coherence tomography angiography (SS-OCTA), and to correlate imaging findings with histology. Methods: Sixty subjects were enrolled: 20 with GA, 20 with intermediate AMD, and 20 healthy controls. SS-OCTA imaging was used to quantify retinal perfusion density (PD) and vessel length density (VLD) in the superficial capillary plexus (SCP), deep capillary plexus (DCP), and full retina. A topographical analysis distinguished regions with and without retinal pigment epithelium (RPE) atrophy in GA eyes. Additionally, flat-mount immunohistochemistry was performed on a donor eye with GA to assess retinal vasculature. Main outcome measures included PD and VLD across SCP, DCP, and full retina, in regions with and without RPE atrophy. Results: Retinal PD and VLD were significantly reduced in GA eyes compared with intermediate AMD eyes, particularly in the DCP. Topographical analysis revealed more pronounced vascular impairment in areas with RPE atrophy, whereas regions without RPE atrophy in GA eyes exhibited perfusion comparable to intermediate AMD and healthy controls. Histological analysis confirmed a substantial reduction in vascular density within atrophic regions. Conclusions: Retinal vascular changes in GA predominantly occur within regions of RPE atrophy. The preservation of perfusion in regions without RPE atrophy suggests that vascular impairment is localized. These findings underscore the importance of regional analysis and histopathologic correlation in understanding vascular remodeling in GA. Future longitudinal OCTA studies are warranted to clarify the temporal progression of these vascular alterations in relation to RPE atrophy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.