Evidence map›Paper›PMID 40874688›Full record

ReviewJournal of evidence-based integrative medicine

Role of Yoga in Distinctly Targeting Modifiable Risk Factors in Type 2 Diabetes to Improve Immuno-Metabolic Axis.

Harshit B Joshi, Aswathy S Nair, Ramya Bellave, Krishna Raghava Hebbar, Anupama Nayak, Nandi Krishnamurthy Manjunath, Shashikiran Umakanth, Basavaraj Hadapad, Manjunath B Joshi

Abstract readReview
In one paragraph

Review in Journal of evidence-based integrative medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Harshit B JoshiDepartment of Ageing Research, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, India.
Aswathy S NairDepartment of Ageing Research, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, India.ORCID 0000-0002-6282-6890
Ramya BellaveDepartment of Ageing Research, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, India.
Krishna Raghava HebbarDivision of Ayurveda, Centre for Integrative Medicine and Research, Manipal Academy of Higher Education, Manipal, India.
Anupama NayakDivision of Ayurveda, Centre for Integrative Medicine and Research, Manipal Academy of Higher Education, Manipal, India.
Nandi Krishnamurthy ManjunathDivision of Life Science, Molecular Bioscience Lab, Swami Vivekananda Yoga Anusandhana Samsthana, Bangalore, India.
Shashikiran UmakanthDr. TMA Pai Hospital, Department of Medicine, Manipal Academy of Higher Education, Manipal, India.
Basavaraj HadapadDivision of Ayurveda, Centre for Integrative Medicine and Research, Manipal Academy of Higher Education, Manipal, India.
Manjunath B JoshiDepartment of Ageing Research, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, India.ORCID 0000-0002-1310-5480

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Modifiable and non-modifiable risk factors in Type 2 Diabetes (T2D) contribute to chronic inflammation characterized by elevated pro-inflammatory mediators and constitutively activated immune cells. Chronic inflammation in T2D leads to perturbations in metabolism, resulting in altered immuno-metabolic axis and further vascular complications. Hence, reducing inflammation by targeting modifiable risk factors such as adiposity, sedentary lifestyle and psychological stress in T2D may facilitate efficient clinical management. Yoga has been shown to improve glucose metabolism, reduce psychological stress, and decrease obesity, hence we sought to review the role of Yoga on cellular mechanisms regulating the immuno-metabolic axis in T2D. Elevated levels of inflammatory mediators such as IL-1b, IL-6, TNF-a, and CRP contributing to insulin resistance are reduced upon practicing Surya Namaskara, Pranayama, and meditation and further improved glycemic index in T2D individuals. Specific Asanas and Pranayama significantly decreased adipokines including leptin, adiponectin, and vaspin in subjects with high BMI, triglycerides and HOMA-IR values, and concomitantly reduced inflammation. Bidirectional activation of inflammatory mediators and stress hormones including epinephrine, catecholamines and cortisol manifesting in diabetes are also reduced upon practising meditation and Yoga. Yoga practices such as Pranayama, Asanas and Mudras improve insulin sensitivity, contribute to weight management, mitigate stress levels in T2D, and maintain immuno-metabolic homeostasis.

Indexed as

Diabetes Mellitus, Type 2YogaHumansInflammationInsulin ResistanceRisk FactorsStress, Psychologicaladiposityimmuno-metabolisminflammationinsulin resistancestresstype 2 diabetesyoga

Identifiers

PMID40874688
PMCPMC12508556

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.