ArticleJournal of veterinary internal medicine
Clonal T Cell Proliferation Induced by Acute Anaplasmosis in a Dog.
Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Acaricidal efficacy and biochemical effects of Cananga odorata essential oil and three selected compounds against Haemaphysalis doenitzi (Acari: Ixodidae).Parasites & vectors · 2026Article
- Clonal T Cell Proliferation Induced by Acute Anaplasmosis in a Dog.Journal of veterinary internal medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A 4-year-old spayed female Golden Retriever was examined for hindlimb lameness, lethargy, poor appetite, and pyrexia 3 weeks after the removal of numerous ticks. Complete blood count revealed moderate thrombocytopenia and mild lymphopenia. A SNAP 4Dx test was negative for Borrelia burgdorferi, Ehrlichia spp., Anaplasma spp., and Dirofilaria immitis. Abdominal ultrasound identified moderate mesenteric lymphadenopathy and regionally hyperechoic mesentery. Joint fluid cytology raised concern for large cell lymphoma. Flow cytometry identified 37% aberrant large CD4+ T cells, suggesting lymphoma. PCR for antigen receptor rearrangement (PARR) testing on the joint fluid confirmed clonal expansion of T cells, further supporting T-cell lymphoma. Peripheral blood PCR was positive for Anaplasma phagocytophilum. The dog's clinical signs and laboratory abnormalities resolved after a 30-day treatment with doxycycline. After treatment, joint fluid analysis, including cytology and flow cytometry, was normal. This case highlights the importance of considering A. phagocytophilum as a differential diagnosis in dogs with a clonal expansion of CD4+ T cells, emphasizing the comprehensive diagnostic approach.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.