Alyssa Richman, Sophie Kogut, Terri Edwards, Joseph Boyd, Princess Rodriguez, Michael Mariani, Mason A Shipley, Kayley A Manuel, Ziyun A Ye, David C Bloom and 2 more
Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Alyssa RichmanDepartment of Biomedical and Health Sciences, University of Vermont, Burlington, Vermont, USA.
Sophie KogutDepartment of Biomedical and Health Sciences, University of Vermont, Burlington, Vermont, USA.
Terri EdwardsDepartment of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, USA.
Joseph BoydDepartment of Biomedical and Health Sciences, University of Vermont, Burlington, Vermont, USA.
Princess RodriguezDepartment of Biomedical and Health Sciences, University of Vermont, Burlington, Vermont, USA.
Michael MarianiDepartment of Biomedical and Health Sciences, University of Vermont, Burlington, Vermont, USA.
Mason A ShipleyDepartment of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0001-8317-3166
Kayley A ManuelDepartment of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0009-0005-5145-4015
Ziyun A YeDepartment of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0009-0007-5819-6957
David C BloomDepartment of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, USA.
Seth FrietzeDepartment of Biomedical and Health Sciences, University of Vermont, Burlington, Vermont, USA.ORCID 0000-0003-4058-3661
Donna M NeumannDepartment of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0002-8115-2254
Funding
UW Vision Research Core - Administrative CoreP30EY016665 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI AKIHIRO IKEDA · 2005 to 2026
$12.6M
Molecular Genetics of HSV ReactivationR01AI048633 · NIAID · UNIVERSITY OF FLORIDA · PI BLOOM, DAVID C. · 2001 to 2023
$7.2M
CTFC Mediated HSV-1 Gene Expression in Latency and ReactivationR01AI134807 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI NEUMANN, DONNA M · 2019 to 2023
$2.1M
Vision Research Training ProgramT32EY027721 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI ROBERT W NICKELLS · 2018 to 2026
$1.5M
McPherson Eye Research Institute Grant Summit ProgramNational Institute of Allergy and Infectious Diseases R01AI048633National Institute of Allergy and Infectious Diseases R01AI134807NEI NIH HHS 2T32EY027721NEI NIH HHS P30 EY016665NEI NIH HHS P30EY016665NEI NIH HHS T32 EY027721NIAID NIH HHS R01 AI048633NIAID NIH HHS R01 AI134807NSF | National Science Foundation Graduate Research Fellowship Program (GRFP) 2137424Research to Prevent Blindness
6 · The paper itself
Abstract
In cellular genomes, CCCTC-binding factor (CTCF) insulators impact transcription over small distances in a one-dimensional manner and over much longer distances in a three-dimensional manner by maintaining chromatin loops. We have previously shown that the latent HSV-1 genome contains CTCF insulators that function to regulate lytic transcription of adjacent genes in a one-dimensional manner. Here, we test the hypothesis that HSV-1 CTCF insulators nucleate chromatin loops to regulate the expression of distance-separated gene regions through three-dimensional organization of viral genomes. We used 4C-seq methods to identify multiple long-range
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.