ArticleEuropean journal of preventive cardiology2025
Peripheral vs. Central Arterial Stiffness and Cardiovascular Events in Older Adults: The Atherosclerosis Risk in Communities (ARIC) study.
Article in European journal of preventive cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Dietary Vitamin Intake and Central and Peripheral Arterial Stiffness in Patients with Long COVID: The BioICOPER Study.Nutrients · 2026Article
- Dietary Mineral Intake and Vascular Health in Patients with Long COVID-19: The BioICOPER Study.Nutrients · 2026Article
- Impact of Parathyroidectomy on Vascular Stiffness: Exploring Pulse Wave Velocity and Renal Resistive Index.The Journal of clinical endocrinology and metabolism · 2026Article
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5 authors.
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Abstract
aimsCarotid-femoral pulse wave velocity (cfPWV) is a representative measure of central arterial stiffness and an independent predictor of cardiovascular disease (CVD). Femoral-ankle PWV (faPWV) represents peripheral arterial stiffness, but its association with CVD has not been specifically investigated.
methodsWe analyzed 3,402 ARIC participants without prior coronary heart disease (CHD), heart failure (HF), or stroke at Visit 5 (2011-13) (mean age 74.8 [4.9] years, 36.1% male, 22.0% Black). faPWV and cfPWV were measured by Omron VP-1000 Plus. The primary outcome was CVD (CHD, HF, and stroke). We used multivariable Cox proportional hazards models.
resultsDuring a median 9.0-year follow-up, 607 CVD events occurred. Overall, faPWV showed an inverse association with CVD, with hazard ratio (HR) for top vs. bottom quartile 0.80 (95%CI 0.64-1.01) and p-for-trend 0.017 in Model 1 (demographically adjusted) and HR 0.86 (0.68-1.09) and p-for-trend 0.096 in Model 2 (further adjusted for CVD risk factors). In contrast, cfPWV was positively associated with CVD in both Models (HR for top vs. bottom quartile 1.22 [0.95-1.56], p-for-trend=0.043 in Model 2). The ratio of cfPWV to faPWV ("cf-fa ratio") showed a stronger association with CVD (HR 1.37 [1.07-1.74], p-for-trend=0.005) than cfPWV. Examining CVD subtypes, the significant contrast in Model 2 was cf-fa ratio and HF.
conclusionsfaPWV showed a borderline significant inverse association with CVD, and cf-fa ratio appeared more strongly associated with CVD than cfPWV. Our findings indicate distinct prognostic implications of central vs. peripheral arterial stiffness and support cf-fa ratio as an alternative measure for CVD risk assessment.
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