Evidence map›Paper›PMID 40874429›Full record

ArticleHead & neck2026

Neck Dissection Reduces Risk of Recurrence in Early-Stage Oral Tongue Cancer.

Jaclyn Lee, Tan Ding, Mae Wimbiscus, Dandan Liu, Melanie D Hicks, Alexander J Langerman, Robert J Sinard, Kyle Mannion, Sarah L Rohde, Eben L Rosenthal and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Head & neck, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jaclyn LeeDepartment of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0001-9804-6995
Tan DingDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Mae WimbiscusVanderbilt University School of Medicine, Nashville, Tennessee, USA.
Dandan LiuVanderbilt University School of Medicine, Nashville, Tennessee, USA.
Melanie D HicksDepartment of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Alexander J LangermanDepartment of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Robert J SinardDepartment of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Kyle MannionDepartment of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Sarah L RohdeDepartment of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Eben L RosenthalDepartment of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Michael C TopfDepartment of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0002-1022-4417

Funding

Vanderbilt Clinical Oncology Research Career Development ProgramK12CA090625 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Debra L. Friedman, Paula Jill Hurley · 2001 to 2026
$16.9M
Augmented Reality to Guide Head and Neck Cancer SurgeryK08CA293255 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Michael Topf · 2024 to 2026
$645k
American Academy of Otolaryngology-Head and Neck Surgery CORE Young Investigator Combined AwardNCI NIH HHS 1K08CA293255-01NCI NIH HHS K08 CA293255NCI NIH HHS K12 CA090625
6 · The paper itself

Abstract

backgroundPatterns of failure in early-stage oral tongue squamous cell carcinoma (OTSCC) managed with surgery alone remain understudied.

methodsRetrospective cohort study from 2000 to 2022 at a single tertiary care center evaluated pT1-T2N0 OTSCC patients who underwent partial glossectomy with or without elective neck dissection (END), without any adjuvant therapy. Predictors of recurrence were analyzed via multivariate Cox proportional hazards model.

resultsThe study included 201 OTSCC patients (131 pT1 and 70 pT2). Eighty patients (40%) underwent glossectomy alone; 121 (60%) underwent glossectomy with END. At a median follow-up of 56 months (IQR 23-82), 63 patients (31%) developed recurrence (21.4% local; 15.9% regional; 1% distant). Positive margins (HR 5.45 [1.9-15.4]), perineural invasion (HR 4.15 [1.8-9.9]), and increasing depth of invasion (DOI) (HR 1.32 [1.1-1.6]) were independently associated with recurrence. Upfront END reduced the risk of recurrence (HR 0.31 [95% CI: 0.15-0.6]), with benefit starting at tumor DOI 2 mm and greater.

conclusionsUpfront END decreases recurrence for pT1-T2N0 OTSCC treated with surgery alone starting at a DOI of 2 mm.

Indexed as

Carcinoma, Squamous CellGlossectomyNeck DissectionNeoplasm Recurrence, LocalTongue NeoplasmsAdultAgedFemaleHumansMaleMiddle AgedNeoplasm StagingProportional Hazards ModelsRetrospective Studiesdepth of invasionearly‐stage OTSCCelective neck dissectionpredictors of recurrencetongue cancer

Identifiers

PMID40874429
PMCPMC12796990

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.