Evidence map›Paper›PMID 40874421›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

A Herbal-Piezoelectric Heterojunction Strategy to Potentiate Bacterial Cuproptosis-Like Death and Remodel the Inflammatory Microenvironment in Infection-Associated Implant Osteomyelitis.

Guannan Zhang, Zehao Li, Ying Lu, Jianbo Song, Xingyu Liang, Peide Han, Xiaohong Yao, Yongqiang Yang, Xiangyu Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Guannan ZhangShanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, 030032, China.
Zehao LiShanxi Key Laboratory of Biomedical Metal Materials, College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan, 030024, China.
Ying LuShanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, 030032, China.
Jianbo SongShanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, 030032, China.
Xingyu LiangThe First Hospital of Shanxi Medical University, Taiyuan, 030001, China.
Peide HanCollege of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan, 030024, China.
Xiaohong YaoShanxi Key Laboratory of Biomedical Metal Materials, College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan, 030024, China.
Yongqiang YangNational Graphene Products Quality Inspection and Testing Center (Jiangsu), Special Equipment Safety Supervision Inspection Institute of Jiangsu Province, Wuxi, 214174, China.
Xiangyu ZhangShanxi Key Laboratory of Biomedical Metal Materials, College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan, 030024, China.ORCID https://orcid.org/0000-0003-3186-8067

Funding

Basic Projects in Research of Shanxi 202203021212095Central Leading Science and Technology Development Foundation of Shanxi Province YDZJSX20231A064Foundation of Shanxi Bethune Hospital 2024GSPYJ21National Natural Science Foundation of China 52171240
6 · The paper itself

Abstract

For infection-associated implant osteomyelitis (IAOM) caused by Staphylococcus aureus, copper-induced bacterial death holds great potential. However, inducing bacterial cuproptosis-like death using low concentrations of copper (Cu) ions remains a challenge. Therefore, a "herbal-piezoelectric heterojunction" (Herbal-Piezo-HJ) is designed by integrating berberine (Ber) with Cu ion-doped Strontium titanate (SrTiO

Indexed as

CopperOsteomyelitisProsthesis-Related InfectionsStaphylococcal InfectionsAnimalsBerberineInflammationMiceReactive Oxygen SpeciesStaphylococcus aureusTitaniumBerberineCopperReactive Oxygen SpeciesTitaniumacoustoelectric therapybacterial cuproptosis‐like deathherbalimmunoregulationosseointegration

Identifiers

PMID40874421
PMCPMC12631926

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.