Evidence map›Paper›PMID 40874391›Full record

ReviewAutism research : official journal of the International Society for Autism Research2025

A Frank Assessment of SHANK: Impacts of Pathogenic Variations in SHANK3 on Preclinical Models of Phelan McDermid Syndrome.

Vic Lin, Samantha M Matta, Julia E Dallman, Suzanne Hosie, Manon Moreau, Ashley E Franks, Thomas Bourgeron, Elisa L Hill-Yardin

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Autism research : official journal of the International Society for Autism Research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. A Frank Assessment of SHANK: Impacts of Pathogenic Variations in SHANK3 on Preclinical Models of Phelan McDermid Syndrome.Autism research : official journal of the International Society for Autism Research · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Vic LinSchool of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia.ORCID 0009-0008-1263-7339
Samantha M MattaSchool of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia.
Julia E DallmanDepartment of Biology, University of Miami, Coral Gables, Florida, USA.
Suzanne HosieSchool of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia.
Manon MoreauHuman Genetics and Cognitive Functions, Institut Pasteur, UMR3571 CNRS, IUF, Université Paris Cité, Paris, France.
Ashley E FranksDepartment of Microbiology, Anatomy and Physiology and Pharmacology, La Trobe University, Bundoora, Victoria, Australia.
Thomas BourgeronHuman Genetics and Cognitive Functions, Institut Pasteur, UMR3571 CNRS, IUF, Université Paris Cité, Paris, France.
Elisa L Hill-YardinSchool of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia.

Funding

Axial Therapeutics
6 · The paper itself

Abstract

Although there are as many as 40 preclinical models of the neurodevelopmental disorder Phelan McDermid syndrome (PMS, or 22q13.3 deletion syndrome), detailed phenotypic analyses to compare the effects of different pathogenic variants and inform treatment design are lacking. Here, we clarify behavioral traits (social, vocalization, repetitive and anxiety-like behavior), developmental trajectories, and motor activity in addition to changes in brain structure and function in 10 widely available Shank3 transgenic mouse models. Although behavioral deficits in Shank3B

Indexed as

Chromosome DisordersMicrofilament ProteinsNerve Tissue ProteinsAnimalsBehavior, AnimalChromosome DeletionChromosomes, Human, Pair 22Disease Models, AnimalHumansMiceMice, TransgenicSocial BehaviorMicrofilament ProteinsNerve Tissue ProteinsSHANK3 protein, humanShank3 protein, mouseautismbehaviorbraingutmousePhelan McDermidSHANK3

Identifiers

PMID40874391
PMCPMC12541686

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.