Evidence map›Paper›PMID 40874311›Full record

ArticleGut microbes2025

Early life infection with

Iti Saraav, Wanyi Huang, Jisun Jung, Rui Xu, Yong Fu, Keely McDonald, Lawrence A Schriefer, Rachel Rodgers, Megan T Baldridge, Rodney D Newberry and 2 more

Abstract read
In one paragraph

Article in Gut microbes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Iti SaraavDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.
Wanyi HuangDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.
Jisun JungDepartment of Internal Medicine, Division of Rheumatology, Washington University School of Medicine, St. Louis, MO, USA.
Rui XuDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.
Yong FuDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.
Keely McDonaldDepartment of Internal Medicine, Division of Gastroenterology, Washington University School of Medicine, St. Louis, MO, USA.
Lawrence A SchrieferDepartment of Medicine, Division of Infectious Diseases, Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0001-6865-8683
Rachel RodgersDepartment of Medicine, Division of Infectious Diseases, Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA.
Megan T BaldridgeDepartment of Medicine, Division of Infectious Diseases, Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0002-7030-6131
Rodney D NewberryDepartment of Internal Medicine, Division of Gastroenterology, Washington University School of Medicine, St. Louis, MO, USA.
Chyi-Song HsiehDepartment of Internal Medicine, Division of Rheumatology, Washington University School of Medicine, St. Louis, MO, USA.
L David SibleyDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0001-7110-0285

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Washington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Jeffrey Wade Brown · 2000 to 2026
$30.8M
Cryptosporidiosis and Oral ToleranceR21AI171858 · NIAID · WASHINGTON UNIVERSITY · PI SIBLEY, L. DAVID · 2023 to 2024
$428k
NCATS NIH HHS UL1 TR002345NCI NIH HHS P30 CA091842NIAID NIH HHS R21 AI171858NIDDK NIH HHS P30 DK052574
6 · The paper itself

Abstract

To examine the effect of early-life infection with

Indexed as

AntigensCryptosporidiosisCryptosporidium parvumAnimalsAnimals, NewbornColonDisease Models, AnimalFemaleImmune ToleranceInflammationInterleukin-1betaMiceMice, Inbred C57BLOvalbuminTh1 CellsT-Lymphocytes, RegulatoryAntigensInterleukin-1betaOvalbuminCryptosporidiumdietary antigendysbiosisenteric infectionintestinal inflammationoral toleranceregulatory T cellsTH1 inflammatory response

Identifiers

PMID40874311
PMCPMC12396125

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.