Evidence map›Paper›PMID 40874301›Full record

ArticleCell cycle (Georgetown, Tex.)

Molecular crossroads: identifying MAPK proteins bridging SMAD and dopamine pathways in breast cancer.

Przemysław Borawski, Tomasz Sirek, Agata Sirek, Nikola Zmarzły, Robert Nowakowski, Piotr Ossowski, Michał Chalcarz, Kacper Boron, Dariusz Boron, Krzysztof Bereza and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell cycle (Georgetown, Tex.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Przemysław BorawskiIndependent Researcher, Włocławek, Poland.
Tomasz SirekDepartment of Medical and Health Sciences, Collegium Medicum, WSB University, Dabrowa Górnicza, Poland.
Agata SirekDepartment of Medical and Health Sciences, Collegium Medicum, WSB University, Dabrowa Górnicza, Poland.
Nikola ZmarzłyDepartment of Medical and Health Sciences, Collegium Medicum, WSB University, Dabrowa Górnicza, Poland.
Robert NowakowskiDepartment of Medical and Health Sciences, Collegium Medicum, WSB University, Dabrowa Górnicza, Poland.
Piotr OssowskiDepartment of Medical and Health Sciences, Collegium Medicum, WSB University, Dabrowa Górnicza, Poland.
Michał ChalcarzDepartment of Medical and Health Sciences, Collegium Medicum, WSB University, Dabrowa Górnicza, Poland.
Kacper BoronDepartment of Plastic Surgery, Faculty of Medicine, Katowice, Poland.
Dariusz BoronDepartment of Medical and Health Sciences, Collegium Medicum, WSB University, Dabrowa Górnicza, Poland.
Krzysztof BerezaDepartment of Mother and Child Health, Faculty of Health Sciences, Institute of Nursing and Midwifery, Jagiellonian University Medical College, Cracow, Poland.
Konrad DziobekDepartment of Gynecology and Obstetrics with Gynecologic Oncology, Ludwik Rydygier Memorial Specialized Hospital, Kraków, Poland.
Nina Skalska-DziobekDepartment of Gynecology and Obstetrics with Gynecologic Oncology, Ludwik Rydygier Memorial Specialized Hospital, Kraków, Poland.
Piotr WyrobiecDepartment of Medical and Health Sciences, Collegium Medicum, WSB University, Dabrowa Górnicza, Poland.
Beniamin Oskar GrabarekDepartment of Medical and Health Sciences, Collegium Medicum, WSB University, Dabrowa Górnicza, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The transforming growth factor-beta (TGF-β)/SMAD signaling pathway, mitogen-activated protein kinase (MAPK) signaling cascade, and dopamine receptor activity are all implicated in tumor progression. This study investigates molecular interactions among these pathways, identifying MAPK proteins that bridge SMAD and dopamine signaling in the context of breast cancer pathogenesis. A cohort of 405 breast cancer patients was categorized into molecular subtypes: luminal A (

Indexed as

Breast NeoplasmsDopamineMAP Kinase Signaling SystemMitogen-Activated Protein KinasesSmad ProteinsFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticGene Regulatory NetworksHumansMicroRNAsProto-Oncogene MasSignal TransductionTriple Negative Breast NeoplasmsDopamineMAS1 protein, humanMicroRNAsMitogen-Activated Protein KinasesProto-Oncogene MasSmad Proteinsbreast cancergene expressionmicroarrayMitogen-Activated Protein Kinase (MAPK) signalingSuppressor of Mothers Against Decapentaplegic (SMAD) pathway

Identifiers

PMID40874301
PMCPMC12439586

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.