Evidence map›Paper›PMID 40874257›Full record

ArticleInternational journal of cancer2026

Sequential HPV16 variant infections in the genital epithelium and anal canal of men.

Racheal S Dube Mandishora, Milena Giulia Gonçalves, Wenyi Fan, Bradley Sirak, Matthew Thomas Ferreira, Richard R Reich, Kimberly Isaacs-Soriano, Martha Abrahamsen, Eduardo Lazcano Ponce, Luisa L Villa and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Long-term intraanal HPV16 infection in men having sex with men with HIV: Persistence or reinfection?Journal of the European Academy of Dermatology and Venereology : JEADV · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Racheal S Dube MandishoraCenter for Immunization and Infection Research in Cancer and the Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA.ORCID https://orcid.org/0000-0003-1154-6829
Milena Giulia GonçalvesCenter for Translational Research in Oncology, Instituto do Cancer do Estado de São Paulo ICESP, Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo FMUSP HC, São Paulo, Brazil.
Wenyi FanDepartment of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, Florida, USA.
Bradley SirakCenter for Immunization and Infection Research in Cancer and the Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA.
Matthew Thomas FerreiraCenter for Translational Research in Oncology, Instituto do Cancer do Estado de São Paulo ICESP, Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo FMUSP HC, São Paulo, Brazil.
Richard R ReichDepartment of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, Florida, USA.
Kimberly Isaacs-SorianoCenter for Immunization and Infection Research in Cancer and the Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA.
Martha AbrahamsenCenter for Immunization and Infection Research in Cancer and the Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA.
Eduardo Lazcano PonceCenter for Population Health Research, National Institute of Public Health, Cuernavaca, Mexico.ORCID https://orcid.org/0000-0003-1259-6369
Luisa L VillaCenter for Translational Research in Oncology, Instituto do Cancer do Estado de São Paulo ICESP, Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo FMUSP HC, São Paulo, Brazil.
Anna R GiulianoCenter for Immunization and Infection Research in Cancer and the Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA.ORCID https://orcid.org/0000-0002-5440-8859
Laura SicheroCenter for Translational Research in Oncology, Instituto do Cancer do Estado de São Paulo ICESP, Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo FMUSP HC, São Paulo, Brazil.

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI Christine O'Connell · 1998 to 2026
$93.5M
Natural History of HPV Infection in Men: The HIM StudyR01CA098803 · NCI · H. LEE MOFFITT CANCER CTR &RES INST · PI GIULIANO, ANNA R. · 2004 to 2014
$18.2M
Investigation of Oral HPV Infection Natural History and Biomarkers of Persistent Infection: The HIM StudyR01CA214588 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI GIULIANO, ANNA R. · 2017 to 2021
$3.6M
NCI NIH HHS P30 CA076292NCI NIH HHS P30-CA076292NCI NIH HHS R01 CA098803NIH HHS R01CA214588
6 · The paper itself

Abstract

This study aimed to assess HPV16 variant period prevalence and sequential acquisition at genital and anal sites in men from the USA and Latin America, using data from the HPV Infection in Men (HIM) Study cohort. Among 635 men with genital and 115 with anal HPV16, 53 men tested positive for any HPV16 variant at both sites, and HPV16 A1 was most prevalent at both sites, more so at the anal canal. Sequential acquisition of HPV16 A1 occurred in 30.4% (genital to anal) and 29.4% (anal to genital). These findings offer insight into HPV16 variant distribution across anatomic sites in men.

Indexed as

Anal CanalGenitalia, MaleHuman papillomavirus 16Papillomavirus InfectionsAdultAgedEpitheliumHumansMaleMiddle AgedPrevalenceanal and mengenitalHPV16HPV‐variants

Identifiers

PMID40874257
PMCPMC13362005

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.