Evidence map›Paper›PMID 40874233›Full record

ArticleJournal of human immunity2025

Mosaic STAT5B gain-of-function associated with demyelinating disease and autoimmunity.

Erica G Schmitt, Nermina Saucier, Samuel I Risma, Sena N Arbag, Ana Kolicheski, Alexander J Paul, Tomi L Toler, Katarina Semkiu, Soe S Mar, Joshua D Milner and 2 more

Abstract read
In one paragraph

Article in Journal of human immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Erica G SchmittDepartment of Pediatrics, Division of Rheumatology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Nermina SaucierDepartment of Pediatrics, Division of Rheumatology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Samuel I RismaDepartment of Pediatrics, Division of Rheumatology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Sena N ArbagDepartment of Pediatrics, Westchester Medical Center, Valhalla, NY, USA.
Ana KolicheskiDepartment of Pediatrics, Division of Rheumatology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Alexander J PaulDepartment of Pediatrics, Division of Rheumatology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Tomi L TolerDepartment of Pediatrics, Division of Genetics and Genomic Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Katarina SemkiuDepartment of Pediatrics, Division of Hematology and Oncology, Washington University School of Medicine, St. Louis, Missouri, USA.
Soe S MarDepartment of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.
Joshua D MilnerDivision of Pediatric Allergy, Immunology and Rheumatology, New York-Presbyterian/ Columbia University Irving Medical Center, New York, NY.
Jeffrey J BednarskiDepartment of Pediatrics, Division of Hematology and Oncology, Washington University School of Medicine, St. Louis, Missouri, USA.
Megan A CooperDepartment of Pediatrics, Division of Rheumatology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.

Funding

STAT3 variants as a rheostat of immune toleranceP01AI155393 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Mark S Anderson · 2022 to 2026
$10.5M
Somatic variants as drivers of genetic errors of immunityP01AI186771 · NIAID · WASHINGTON UNIVERSITY · PI Dusan Bogunovic, Megan Anne Cooper · 2025 to 2026
$7.5M
Human ISG15 and USP18 Deficiencies Underlying Type I InterferonopathiesR01AI127372 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Dusan Bogunovic · 2017 to 2026
$4.7M
Mechanisms Contributing to T Cell Immune Dysregulation in STAT3 Gain-of-FunctionK08AI182483 · NIAID · WASHINGTON UNIVERSITY · PI Erica G Schmitt · 2024 to 2026
$581k
Genetic Mosaicism in Inborn Errors of ImmunityR21AI168957 · NIAID · WASHINGTON UNIVERSITY · PI COOPER, MEGAN ANNE · 2022 to 2023
$433k
NIAID NIH HHS K08 AI182483NIAID NIH HHS P01 AI155393NIAID NIH HHS P01 AI186771NIAID NIH HHS R01 AI127372NIAID NIH HHS R21 AI168957
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

eosinophiliaimmune deficiencyinborn errors of immunitySTAT5B

Identifiers

PMID40874233
PMCPMC12379004

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.