Evidence map›Paper›PMID 40874206›Full record

SynthesisFrontiers in veterinary science2025

Pharmaco-toxicological aspects of thymol in veterinary medicine. A systematic review.

Denisa Pérez Gaudio, Mery Giantin, Marianna Pauletto, Mauro Dacasto

Abstract readSystematic Review
In one paragraph

Synthesis in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Denisa Pérez GaudioLaboratorio de Toxicología, Depto. de Fisiopatología, Facultad de Ciencias Veterinarias, Centro de Investigación Veterinaria de Tandil (CIVETAN), Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil, Buenos Aires, Argentina.
Mery GiantinDepartment of Comparative Biomedicine and Food Science, Division of Veterinary Pharmacology and Toxicology, University of Padua, Padua, Italy.
Marianna PaulettoDepartment of Comparative Biomedicine and Food Science, Division of Veterinary Pharmacology and Toxicology, University of Padua, Padua, Italy.
Mauro DacastoDepartment of Comparative Biomedicine and Food Science, Division of Veterinary Pharmacology and Toxicology, University of Padua, Padua, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Thymol, a phenolic compound present in essential oils, has shown promising pharmacological properties and potential veterinary applications. This systematic review aims to evaluate the pharmacological and toxicological effects of thymol on animals. Materials and methods: A comprehensive search following PRISMA 2020 guidelines was conducted across databases including PubMed, Scopus, Google Scholar, Web of Science, and LILACS. Various health descriptors, medical subject headings terms, and their synonyms were used to identify studies examining thymol's effects in animals, including its Results: A total of 1.472 records were identified, with 176 meeting inclusion criteria. Studies spanned from 2012 to 2024, indicating that thymol exhibits antimicrobial, antiviral, antifungal, antiparasitic, anti-inflammatory, and antioxidant properties, among others. However, thymol displays dose-dependent toxicity, especially at high levels, affecting mainly the liver and kidneys. Discussion: Thymol holds substantial potential as a therapeutic agent in veterinary medicine due to its beneficial effects and relatively low toxicity. Nonetheless, further research is needed to establish safe and effective dosages across different animal species. Systematic review registration: https://doi.org/10.17605/OSF.IO/B6SF9.

Indexed as

in vitro and in silico studiesin vivopharmacological effectsthymoltoxicological effectsveterinary applications

Identifiers

PMID40874206
PMCPMC12379064

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.