Evidence map›Paper›PMID 40874167›Full record

ArticleERJ open research2025

Engin L, Caroline A Owen, Fred Reid, Claudia Cabrera, Charles S Haworth, Rod Hughes

Abstract read
In one paragraph

Article in ERJ open research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Engin LClinical Development, Early R&I, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.ORCID https://orcid.org/0000-0001-5879-6329
Caroline A OwenClinical Development, Early R&I, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA.ORCID https://orcid.org/0000-0003-4377-3591
Fred ReidClinical Development, Early R&I, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
Claudia CabreraEvidence, R&I, BioPharmaceuticals Medical, Gothenburg, Sweden.
Charles S HaworthCambridge Centre for Lung Infection, Royal Papworth Hospital, Cambridge, UK.
Rod HughesClinical Development, Early R&I, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.

Funding

UAB CF Research and Translation Core CenterP30DK072482 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AMIT GAGGAR · 2007 to 2026
$23.0M
NIDDK NIH HHS P30 DK072482
6 · The paper itself

Abstract

Introduction: Methods: This was a US retrospective cohort study using the TriNetX platform between 2008 and 2019. Adult patients with (wPsA) or without (w/oPsA) PsA airway infection were included. Date of first exacerbation corresponded to the index date, and patients were followed for up to 5 years post index. Risk ratios (RR) for hospitalisation, subsequent exacerbation, mortality and incidence of pre-specified CV events were estimated. Propensity score matching (PSM) was used to balance baseline characteristics. Results: After PSM, patients wPsA infection were at a greater risk of hospitalisation (RR: 1.40; 95% CI: 1.19-1.64), subsequent exacerbation (RR: 1.70; 95% CI: 1.53-1.90) and mortality (RR: 1.37; 95% CI: 1.20-1.56) than patients w/oPsA. PsA infection was associated with a higher risk of dysrhythmias (RR: 1.32; 95% CI: 1.13-1.54), inflammatory heart disease (RR: 2.09; 95% CI: 1.29-3.37), other cardiac disorders (RR: 1.40; 95% CI: 1.14-1.72), thrombotic disorders (RR: 1.31; 95% CI: 1.01-1.68), major adverse cardiovascular events (RR: 1.35; 95% CI: 1.19-1.52) and any CV outcome (RR: 1.42; 95% CI: 1.24-1.62). Conclusion: PsA infection in patients with BE is associated with an increased risk of CV events following a baseline exacerbation. These data highlight the multisystemic nature of BE and the need to raise awareness of the potential increased risk of CV events in patients with BE experiencing exacerbations.

Identifiers

PMID40874167
PMCPMC12378861

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.