ArticleRSC advances2025
Regioselective Ru(ii)-catalyzed C-H alkenylation and annulation of indoles: a direct approach to fused lactone scaffolds.
Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
In this work, we offer a method for selectively alkenylating C5-H and then annulating indole-4-carboxylic acid derivatives using ruthenium(ii) as a catalyst. Our approach facilitates the effective formation of fused lactone structures by employing a weakly coordinating carboxylic acid group at the C4 position as a guiding group. The reaction process starts with an alkenylation at the C5 position of the indole ring, followed by an intramolecular Michael addition to produce annulated lactones in high yields. This is the first report of ruthenium-catalyzed lactone synthesis at the C5 position of indoles
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