ArticleFrontiers in neurology2025
Exploring the relationship between temperament traits, psychological symptoms, and functional disability assessed with the WHODAS 2.0 in persons with multiple sclerosis.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Measurement Properties and Applications of WHODAS 2.0 in Multiple Sclerosis: A Systematic Review.Medical sciences (Basel, Switzerland) · 2026Pooled it
- Affective temperament profiles in patients with herpes zoster and postherpetic neuralgia: a comparative analysis using TEMPS-A scale.Frontiers in psychiatry · 2026Article
Corrections and comments
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Authors and funding
11 authors.
Funding
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Abstract
Background: The relationship between psychological comorbidity and functional impairment in multiple sclerosis (MS) remains to be thoroughly investigated. This study examined the associations between temperament traits, psychological comorbidities, and disability as measured by the World Health Organization Disability Assessment Schedule (WHODAS) 2.0 in persons with Relapsing-Remitting Multiple Sclerosis (RRMS). Methods: In this cross-sectional study, persons with RRMS underwent a comprehensive assessment of temperament profiles, psychological status, and functional disability. Assessment tools included the Depression Anxiety Stress Scale (DASS-21) and the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego Autoquestionnaire (TEMPS-A) short form. Functional status was evaluated using the 36-item WHODAS 2.0. Multivariate regression analyses were performed to evaluate relationships between variables. Results: The study cohort comprised 105 persons with RRMS Hierarchical regression models showed that age and disease duration were significant predictors, with age positively associated with D02 and D06 dimensions, and disease duration linked to D02, D05, and D06 WHODAS 2.0 dimensions. Among temperament traits, hyperthymic temperament showed negative associations across multiple dimensions. Anxiety had strong positive association with disability. Model fit improved significantly with each step, with Step 3 explaining additional variance. Conclusion: These findings demonstrate significant associations between temperamental characteristics, particularly hyperthymic traits, -anxiety, and functional disability in persons with RRMS. Future research should investigate these relationships over time to understand causal links and create better treatments to slow disability progression. These findings could help improve how we assess and treat patients.
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