Evidence map›Paper›PMID 40874029›Full record

ArticlePNAS nexus2025

Notch signaling in germ line stem cells controls reproductive aging in

Zuzana Kocsisova, Elena D Bagatelas, Jesus Santiago-Borges, Hanyue Cecilia Lei, Brian M Egan, Matthew C Mosley, Aaron M Anderson, Daniel L Schneider, Tim Schedl, Kerry Kornfeld

Abstract read
In one paragraph

Article in PNAS nexus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Apoptosis promotes fertility inbioRxiv : the preprint server for biology · 2025
    Article
  3. Article
  4. Non-autonomy of age-related morphological changes in thebioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zuzana KocsisovaDepartment of Developmental Biology, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO 63108, USA.
Elena D BagatelasDepartment of Developmental Biology, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO 63108, USA.ORCID https://orcid.org/0000-0001-7379-1075
Jesus Santiago-BorgesDepartment of Developmental Biology, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO 63108, USA.
Hanyue Cecilia LeiDepartment of Developmental Biology, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO 63108, USA.ORCID https://orcid.org/0000-0001-5944-1167
Brian M EganDepartment of Developmental Biology, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO 63108, USA.
Matthew C MosleyDepartment of Developmental Biology, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO 63108, USA.ORCID https://orcid.org/0000-0002-2181-923X
Aaron M AndersonDepartment of Developmental Biology, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO 63108, USA.ORCID https://orcid.org/0000-0003-1797-5229
Daniel L SchneiderDepartment of Developmental Biology, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO 63108, USA.ORCID https://orcid.org/0000-0001-9408-8901
Tim SchedlDepartment of Genetics, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO 63108, USA.ORCID https://orcid.org/0000-0003-2148-2996
Kerry KornfeldDepartment of Developmental Biology, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO 63108, USA.ORCID https://orcid.org/0000-0002-6042-5241

Funding

Control of germline stem cells and the switch to meiotic development in C. elegansR35GM152192 · NIGMS · WASHINGTON UNIVERSITY · PI TIM SCHEDL · 2024 to 2026
$1.0M
NIGMS NIH HHS R35 GM152192
6 · The paper itself

Abstract

Adult stem cells maintain and rejuvenate a wide range of tissues, and the progressive, age-related decline of adult stem cells is a hallmark of aging. We propose that the

Indexed as

germlineNotchnutrient sensingreproductive agingstem cells

Identifiers

PMID40874029
PMCPMC12380048

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.