Evidence map›Paper›PMID 40874003›Full record

ArticleJournal of animal science and technology2025

Genome-wide association and fine-mapping analyses identify novel candidate genes affecting serum cortisol levels using imputed whole-genome sequencing data in pigs.

Tae-Hee Kim, Hyeon-Ah Kim, Jae-Bong Lee, Dongwon Seo, Yuju Lee, Yong Jun Kang, Sang-Geum Kim, Sang-Hyun Han, Seung-Hwan Lee, Cedric Gondro and 2 more

Abstract read
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In one paragraph

Article in Journal of animal science and technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tae-Hee KimDepartment of Animal Resources Science, Kongju National University, Yesan 32439, Korea.ORCID https://orcid.org/0009-0009-5551-1434
Hyeon-Ah KimSubtropical Livestock Research Center, National Institute of Animal Science, Rural Development Administration, Jeju 63242, Korea.ORCID https://orcid.org/0000-0002-4203-9857
Jae-Bong LeeKorea Zoonosis Research Institute, Jeonbuk National University, Iksan 54531, Korea.ORCID https://orcid.org/0000-0001-9331-8146
Dongwon SeoTNT Research Co., Jeonju 54810, Korea.ORCID https://orcid.org/0000-0003-0548-7068
Yuju LeeDepartment of Animal Resources Science, Kongju National University, Yesan 32439, Korea.ORCID https://orcid.org/0009-0008-0806-0354
Yong Jun KangSubtropical Livestock Research Center, National Institute of Animal Science, Rural Development Administration, Jeju 63242, Korea.ORCID https://orcid.org/0000-0001-8949-7831
Sang-Geum KimSubtropical Livestock Research Center, National Institute of Animal Science, Rural Development Administration, Jeju 63242, Korea.ORCID https://orcid.org/0000-0002-0245-0465
Sang-Hyun HanHabitat Conservation Division, Korean National Park Research Institute, Korea National Park Service, Yongju 36015, Korea.ORCID https://orcid.org/0000-0002-6615-2811
Seung-Hwan LeeDivision of Animal and Dairy Science, Chungnam National University, Daejeon 34134, Korea.ORCID https://orcid.org/0000-0003-1508-4887
Cedric GondroDepartment of Animal Science, Michigan State University, East Lansing, MI 48824, USA.ORCID https://orcid.org/0000-0003-0666-656X
Hee-Bok ParkDepartment of Animal Resources Science, Kongju National University, Yesan 32439, Korea.ORCID https://orcid.org/0000-0002-9418-1898
In-Cheol ChoSubtropical Livestock Research Center, National Institute of Animal Science, Rural Development Administration, Jeju 63242, Korea.ORCID https://orcid.org/0000-0003-3459-1999

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In swine breeding programs, it has now become critically important to emphasize selection for resilience to external environmental stress factors that have negatively impacted the productivity of pigs, such as those due to climate change induced temperature increases, or the intensification of housing environments. Secretion of cortisol, a neurophysiological change mediated by the hypothalamic-pituitary-adrenal axis, is a central mechanism in the biological stress response. This hormone is closely related to pig robustness and health and can serve as an informative indicator of stress resistance and robustness in pigs. To identify positional candidate genes and their genetic variants influencing blood cortisol levels, we conducted genome-wide association study (GWAS), joint linkage and linkage disequilibrium (LALD) mapping and Bayesian fine-mapping analysis in an F

Indexed as

Candidate geneFine-mappingImputed whole-genome sequenceSerum cortisol levels

Identifiers

PMID40874003
PMCPMC12380018

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.