Evidence map›Paper›PMID 40873988›Full record

ArticleFrontiers in public health2025

Scanning the horizon of personalized prevention research: an overview of ongoing European funded initiatives.

Alessandra Maio, Sara Farina, Tommaso Osti, Salvatore Di Grande, Roberta Pastorino, Stefania Boccia

Abstract readScoping Review
In one paragraph

Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alessandra MaioUniversity Department of Life Science and Public Health, Section of Hygiene, Università Cattolica del Sacro Cuore, Rome, Italy.
Sara FarinaUniversity Department of Life Science and Public Health, Section of Hygiene, Università Cattolica del Sacro Cuore, Rome, Italy.
Tommaso OstiUniversity Department of Life Science and Public Health, Section of Hygiene, Università Cattolica del Sacro Cuore, Rome, Italy.
Salvatore Di GrandeUniversity Department of Life Science and Public Health, Section of Hygiene, Università Cattolica del Sacro Cuore, Rome, Italy.
Roberta Pastorino *University Department of Life Science and Public Health, Section of Hygiene, Università Cattolica del Sacro Cuore, Rome, Italy.
Stefania Boccia *University Department of Life Science and Public Health, Section of Hygiene, Università Cattolica del Sacro Cuore, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Non-communicable diseases represent a significant burden on global healthcare, necessitating innovative strategies to enhance prevention and management. Personalized prevention, an emerging approach leveraging omics data to tailor interventions, holds promise for improving risk stratification, early diagnosis, and preventive strategies. To gain insights on the latest funding investments in this field, we mapped European Commission (EC)-funded research projects on personalized prevention for non-communicable diseases. Materials and methods: We carried out a scoping review of gray literature sources, following the Arksey and O'Malley framework, combined with expert consultations to validate findings and address data gaps. Inclusion criteria focused on projects that began or were ongoing in 2024 (from January 1st to December 31st). Results: We identified 67 projects supported by a total amount of €511.9 million from EC funding. The main programs include Horizon Europe, Horizon 2020, and EU4Health. In particular, Horizon Europe funds 51% of these projects, with a total allocation of €253.8 million, 44% of which specifically address cancer. Overall, 48% of the projects target cancer, followed by neurological and psychiatric diseases (15%), cardiovascular diseases (13%), metabolic disorders (9%), and other NCDs (16%). In terms of prevention levels, 21% of the projects are dedicated to primary prevention, 41% to secondary prevention, and 38% to tertiary prevention. Conclusion: The EC's investment in personalized prevention is predominantly directed toward cancer, reflecting the goals of the Cancer Mission and the European Beating Cancer Plan. Research on tertiary prevention remains less prominent, likely due to its already established clinical applications, while the emphasis on primary and secondary prevention is reassuring, considering the current gaps in clinical utility evidence in these areas.

Indexed as

Noncommunicable DiseasesPrecision MedicinePreventive MedicineEuropeHumansEuropean Commissionnon-communicable diseasespersonalized preventionprojectsresearch

Identifiers

PMID40873988
PMCPMC12378169

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.