ArticleFrontiers in aging neuroscience2025
Relationship between the platelet-to-lymphocyte ratio and in-hospital mortality of ischemic stroke patients in the intensive care unit.
Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- COVID-19 Fog Symptoms Are Associated with Brain Metabolism and Platelet-to-Lymphocyte Ratio-A Cross-Sectional Analysis of the COVMENT Trial Baseline Data.Journal of clinical medicine · 2026Article
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6 authors.
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Abstract
Background: The relationship between the platelet-to-lymphocyte ratio (PLR) and the prognosis of patients with ischemic stroke was unclear. Objective: This study aimed to explore the correlation between PLR levels and in-hospital mortality in ischemic stroke patients admitted to the intensive care unit (ICU). Methods: A retrospective cohort study was conducted using data from the MIMIC-IV database. Demographic and clinical data of all participants were collected, and the study outcome was in-hospital mortality. Patients were divided into three groups based on the tertiles of PLR: low PLR group (PLR < 0.88), intermediate PLR group (0.88 ≤ PLR < 1.73), and high PLR group (PLR ≥ 1.73). Multivariable-adjusted logistic regression analysis, curve fitting, interaction analysis, and threshold analysis were performed to evaluate the relationship between PLR levels and in-hospital mortality in ischemic stroke patients in the ICU. Results: A total of 1,002 critically ill patients with ischemic stroke were included, with an average PLR level of 1.88 ± 2.34. The overall in-hospital mortality rate was 12.48%, with mortality rates of 7.38% in the low PLR group, 8.96% in the intermediate PLR group, and 21.15% in the high PLR group. A non-linear J-shaped relationship was found between PLR and in-hospital mortality. The study found that when the PLR value was less than 4.21, there was a positive correlation between PLR and in-hospital mortality. In the subgroup analysis, no statistically significant interactions were found among the subgroups. Conclusion: In the ICU setting, PLR levels were independently associated with in-hospital mortality in critically ill patients with ischemic stroke. When PLR was less than 4.21, this emphasized the importance of close monitoring by ICU physicians.
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