ArticleCureus2025
Ibuprofen-Induced Toxic Epidermal Necrolysis: Report of a Fatal Case.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ibuprofen is a widely used and easily accessible medication that belongs to the nonsteroidal anti-inflammatory drug class. Its most common adverse effects are gastrointestinal. However, there are a few reported cases of fatal side effects. We report a case of toxic epidermal necrolysis (TEN) potentially affecting more than 80% of the total body surface area, triggered by ibuprofen in a 77-year-old female patient after taking it for the first time. The diagnosis of TEN was confirmed through skin biopsy. The severe mucocutaneous reactions, Stevens-Johnson syndrome and toxic epidermal necrolysis, are characterized by necrosis and skin sloughing. Both share the same pathophysiology; however, they differ based on the total body surface area affected. Toxic epidermal necrolysis is defined as an affected body surface area greater than 30%, so early diagnosis and identification of the cause are crucial to determine its course and prognosis.
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